6201-88-3

Basic information

• Product Name: 2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid
• Synonyms: 2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid
• CAS NO: 6201-88-3
• Molecular Weight: 297.083
• Mol File: 6201-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid(6201-88-3)
• EPA Substance Registry System: 2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid(6201-88-3)

Safety Data

• Hazardous Substances Data: 6201-88-3(Hazardous Substances Data)

Upstream product

• 69-72-7 salicylic acid 
• 89-55-4 5-bromosalicyclic acid 

Downstream Products

• 1349902-63-1 (NH₄)[Ag(2-hydroxyl-3-carboxyl-5-bromobenzenesulfonic acid(-2H))(NH₃)(H₂O)] 

Relevant articles and documents

A new process to prepare 3,6-dichloro-2-hydroxybenzoic acid, the penultimate intermediate in the synthesis of herbicide dicamba

Glyphosate [N-(phosphonomethyl)glycine] is a broad spectrum, post-emergent herbicide that is among the most widely used agrochemicals globally. Over the past 30 years, there has been a development of glyphosate-resistant weeds, which pose a significant challenge to growers and crop scientists, resulting in lower crop yields and increased costs. 3,6-Dichloro-2-methoxybenzoic acid (dicamba) is the active ingredient in XtendiMax a standalone herbicide developed by Bayer Crop Science to control broadleaf weeds, including glyphosate-resistant species. 3,6-Dichloro-2-hydroxybenzoic acid (3,6-DCSA) is the penultimate intermediate in the synthesis of dicamba. Existing dicamba manufacturing routes utilize a high temperature, high pressure Kolbe-Schmitt carboxylation to prepare 3,6-DCSA. Described in this Letter is a new, non-Kolbe-Schmitt process to prepare 3,6-DCSA from salicylic acid in four chemical steps.