62017-16-7Relevant articles and documents
New free-radical halogenations of alkanes, catalysed by N-hydroxyphthalimide. Polar and enthalpic effects on the chemo- and regioselectivity
Minisci, Francesco,Porta, Ombretta,Recupero, Francesco,Gambarotti, Cristian,Paganelli, Roberto,Pedulli, Gian Franco,Fontana, Francesca
, p. 1607 - 1609 (2007/10/03)
Reactions of alkanes with different halogenating systems are compared in order to explore the reactivity of phthalimido-N-oxyl radical in hydrogen abstraction; the importance of polar effects is emphasised.
Dinucleotide and oligonucleotide analogues
-
, (2008/06/13)
PCT No. PCT/GB97/00651 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Nov. 3, 1997 PCT Pub. No. WO97/35869 PCT Pub. Date Oct. 2, 1997A compound which is a dinucleotide analogue of formula or a salt thereof, where B1 and B2 are each independently a monovalent nucleoside base radical, R1 is hydrogen or Y1, R2 and R3 are each independently hydrogen, halogen, hydroxy or -OY2, R4 is hydrogen, halogen, hydroxy, -OY3 or R7, R5 is hydrogen, halogen or R8, R6 is hydrogen, Y4 or a phosphoramidyl group, Z is a group of formula II, III or IV where R9 is hydrogen, halogen, hydroxy, -OY5 or R13, R10 is hydrogen, halogen or R14, R11 is hydroxy, R15 or -OR15 where R15 is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, and R12 is hydrogen, R12a or -OCOR12a where R12a is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, Y1, Y2, Y3, Y4 and Y5 are each indpendently a hydroxy-protecting group, and R7, R8, R13 and R14 are each independently a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group.
THE LONG-RANGE ACTION OF THE POLAR EFFECT OF SUBSTITUENTS ON THE ABSTRACTION OF HYDROGEN IN FREE-RADICAL CHLORINATION PROCESSES
Aver'yanov, V. A.,Ruban, S. G.,Klykova, M. B.,Golubev, V. E.
, p. 435 - 439 (2007/10/02)
The free-radical chlorination of 1-chloroalkanes between C3 and C6 at 263 deg K was studied under conditions with wide variation in the concentrations of the substrates in benzene.By analysis of the products from chlorination of the pure substrates it was shown that the deactivating effect of the polar substituent does not extend beyond the third carbon atom and is mainly determined by the inductive effect.In the transition to an aromatic solvent the deactivating effect on the substituent extends to the fourth carbon atom.The results are substantiated in terms of a contribution from dipole-dipole interaction between the substituent and the polar form of the transition state to the polar effect of the substituents.
