620601-77-6 Usage
General Description
(R)-1-CBZ-2-CYANO-PYRROLIDINE is a chemical compound that belongs to the class of pyrrolidine derivatives. It is a chiral compound with a (R)-configuration and a carbobenzyloxy (CBZ) functional group attached to the nitrogen atom. The presence of a cyano group at the 2-position of the pyrrolidine ring makes it a versatile intermediate for the synthesis of various pharmaceuticals and agrochemicals. (R)-1-CBZ-2-CYANO-PYRROLIDINE has been used as a building block in the synthesis of complex organic molecules and has shown potential as a key intermediate in the production of drugs with therapeutic applications. Its unique structural properties and reactivity make it valuable for chemical research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 620601-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,0,6,0 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 620601-77:
(8*6)+(7*2)+(6*0)+(5*6)+(4*0)+(3*1)+(2*7)+(1*7)=116
116 % 10 = 6
So 620601-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O2/c14-9-12-7-4-8-15(12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-8,10H2/t12-/m1/s1
620601-77-6Relevant articles and documents
Total Synthesis of the Marine Natural Product Hemiasterlin by Organocatalyzed α-Hydrazination
Lang, Jan Hendrik,Jones, Peter G.,Lindel, Thomas
, p. 12714 - 12717 (2017/09/25)
An efficient synthesis of the potently cytotoxic marine peptide hemiasterlin is presented. The tetramethyltryptophan moiety is assembled by tert-prenylation of indole, followed by the high-yielding organocatalyzed α-hydrazination of a sterically congested aldehyde with excellent enantioselectivity. 2-Bromo-N-ethylpyridinium tetrafluoroborate (BEP)-mediated peptide coupling completes the synthesis, being the first approach that does not employ chiral auxiliaries. A novel phenonium-type rearrangement of the indole system occurred when subjecting dihydroxylated 3-tert-prenylindole to Mitsunobu conditions.
ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES and INFLAMMATION
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Page/Page column 29-30, (2009/04/24)
Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
