620633-09-2Relevant articles and documents
Potent, selective pyrimidinetrione-based inhibitors of MMP-13
Reiter, Lawrence A.,Freeman-Cook, Kevin D.,Jones, Christopher S.,Martinelli, Gary J.,Antipas, Amy S.,Berliner, Martin A.,Datta, Kaushik,Downs, James T.,Eskra, James D.,Forman, Michael D.,Greer, Elaine M.,Guzman, Roberto,Hardink, Joel R.,Janat, Fouad,Keene, Nandell F.,Laird, Ellen R.,Liras, Jennifer L.,Lopresti-Morrow, Lori L.,Mitchell, Peter G.,Pandit, Jayvardhan,Robertson, Donald,Sperger, Diana,Vaughn-Bowser, Marcie L.,Waller, Darra M.,Yocum, Sue A.
, p. 5822 - 5826 (2007/10/03)
Using SAR from two related series of pyrimidinetrione-based inhibitors, compounds with potent MMP-13 inhibition and >100-fold selectivity against other MMPs have been identified. Despite high molecular weights, c log Ps, and polar surface areas, the compo
