62124-70-3

Basic information

• Product Name: 5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
• CAS NO: 62124-70-3
• Molecular Formula: C₇H₄N₂S₃
• Molecular Weight: 212.3151
• Mol File: 62124-70-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 409.6°C at 760 mmHg
• Flash Point: 201.5°C
• Density: 1.59g/cm³
• Vapor Pressure: 1.52E-06mmHg at 25°C
• Refractive Index: 1.803
• CAS DataBase Reference: 5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione(62124-70-3)
• EPA Substance Registry System: 5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione(62124-70-3)

Safety Data

• Hazardous Substances Data: 62124-70-3(Hazardous Substances Data)

Upstream product

• 75399-07-4 methyl 3-oxo-3-(pyrazin-2-yl)propanoate 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 98-97-5 2-pyrazylcarboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor which is strongly associated with tumor survival, progression, and therapeutic resistance. Accordingly, it has been suggested that the inhibition of the HIF-1 pathway can suppress tumor, and it has become an important therapeutic target. In present study, oltipraz, its metabolite M2, and their derivatives were synthesized and evaluated as HIF-1α inhibitors. Among the synthesized, benzyl-substituted pyrrolo[1,2-a]pyrazine 2g most potently inhibited HIF-1α protein accumulation (81% at 10 μM) and VEGF, GLUT-1 transcription (77% and 92% at 10 μM, respectively).