62142-03-4

Basic information

• Product Name: Benzamide, N-cyclohexyl-2-iodo-
• CAS NO: 62142-03-4
• Molecular Formula: C13H16INO
• Molecular Weight: 329.181
• Mol File: 62142-03-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, N-cyclohexyl-2-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-cyclohexyl-2-iodo-(62142-03-4)
• EPA Substance Registry System: Benzamide, N-cyclohexyl-2-iodo-(62142-03-4)

Safety Data

• Hazardous Substances Data: 62142-03-4(Hazardous Substances Data)

Upstream product

• 609-67-6 2-Iodobenzoyl chloride 
• 108-91-8 cyclohexylamine 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 1374227-82-3 C₂₁H₂₁NO 
• 17799-67-6 3-cyclohexyl-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one 
• 1454933-29-9 N-cyclohexyl-2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamide 
• 2527-02-8 2-cyclohexyl-1,2-benzisothiazol-3(2H)-one 
• 80006-76-4 1-Chloro-2-cyclohexyl-1,2-dihydro-1λ³-benzo[d][1,2]iodazol-3-one 
• 80006-72-0 C₁₃H₁₆Cl₂INO 
• 2133-65-5 N-cyclohexylphthalimide 

Relevant articles and documents

Convenient synthesis of benziodazolone: New reagents for direct esterification of alcohols and amidation of amines

Hypervalent iodine heterocycles represent one of the important classes of hypervalent iodine reagents with many applications in organic synthesis. This paper reports a simple and convenient synthesis of benziodazolones by the reaction of readily available iodobenzamides with m-chloroperoxybenzoic acid in acetonitrile at room temperature. The structure of one of these new iodine heterocycles was confirmed by X-ray analysis. In combination with PPh3 and pyridine, these benziodazolones can smoothly react with alcohols or amines to produce the corresponding esters or amides of 3-chlorobenzoic acid, respectively. It was found that the novel benziodazolone reagent reacts more efficiently than the analogous benziodoxolone reagent in this esterification.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Synthesis of 2-(1,2,3-Triazolyl)benzamide Derivatives by a Copper(I)-Catalyzed Multicomponent Reaction

The copper-catalyzed multicomponent reaction of 2-iodobenzamides, NaN3, and terminal alkynes for the synthesis of 2-(1,2,3-triazolyl)benzamide derivatives was achieved in a one-step process over a short period of time under mild conditions. The transformation involved a C(aryl)–N bond formation process followed by an azide–alkyne cycloadditon reaction. The absence of external base was crucial for the preferred reaction pathway to occur.