62187-35-3Relevant articles and documents
Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
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, (2008/06/13)
Process for preparing carboxylic acids by converting a glycidonitrile to a 2-oxopropionitrile via use of an ionic Lewis acid, and conversion of the 2-oxopropionitrile to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. The process is especially useful for the preparation of 2-(p-isobutylphenyl)propionic acid, (lbuprofen), also known as Motrin, a known and highly active antiinflammatory agent as well as a host of other carboxylic acids which are known in the art as useful compounds.