6220-43-5Relevant articles and documents
Preparation method of 4-ethoxy-1H-pyridine-2-ketone
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Paragraph 0026; 0027, (2019/09/14)
The invention discloses a preparation method of 4-ethoxy-1H-pyridine-2-ketone. The method comprises the following steps: dissolving 2,4-dichlorine-pyrimidine in solvent adding sodium ethoxide to reactto obtain 2-chlorine-4-ethoxy-pyrimidine; dissolving the 2-chlorine-4-ethoxy-pyrimidine in solvent and hydrolyzing to obtain the 4-ethoxy-1H-pyridine-2-ketone in alkaline condition. The preparation method of 4-ethoxy-1H-pyridine-2-ketone is simple, the raw material is easy to obtain, the product is easy to separate, the reaction condition is mild and easy to control, and the ketone is suitable for large-scale production. At that same time, chlorine gas, which is toxic gas, is not used in the two-step reaction, so that the environmental protection of the preparation is improved.