62205-56-5Relevant articles and documents
TRIPTOLIDE CONJUGATES AND USES THEREOF
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, (2022/03/07)
This disclosure provides triptolide-conjugates, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, as well methods of using such compounds in the treatment of conditions/diseases, such as those relating to cancer, immunomodulation and/or inflammation.
Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides
Van Roon, Anne-Marie M.,Aguilera, Begona,Cuenca, Francisco,Van Remoortere, Alexandra,Van Der Marel, Gijsbert A.,Deelder, Andre M.,Overkleeft, Herman S.,Hokke, Cornelis H.
, p. 3553 - 3564 (2007/10/03)
Complex multifucosylated oligosaccharides are structural elements of glycoprotein and glycolipid subsets of larval, egg, and adult stages of Schistosoma, the parasitic worms that cause schistosomiasis, a serious disease affecting more than 200 million peo
Large scale synthesis of linker-modified sialyl Lewis(X), Lewis(X) and N-acetyllactosamine
Kretzschmar, Gerhard,Stahl, Wilhelm
, p. 6341 - 6358 (2007/10/03)
The synthesis of sialyl-Lewis(X) (1b), Lewis(X) (2) and N- acetyllactosamine (3), each being attached to the 1β-O-(6-amino)hexyl handle, were scaled up to gram amounts to obtain sufficient material for thorough pharmaceutical evaluations and for derivatisations aiming at more potent selectin antagonists. The disaccharide 3 was synthesised from inexpensive lactose to provide a versatile building block, either to be used for alternative approaches to the Lewis type oligosaccharides, or to prepare polyvalent LacNAc templates to be further elaborated by glycosyltransferase reactions. All syntheses were directed to reasonable large scale procedures, especially by minimising the number of steps and the use of heavy metal salts in glycosylations.