62224-16-2

Basic information

• Product Name: Methyl 4-bromothiophene-2-carboxylate
• Synonyms: 4-Bromo-2-(carbomethoxy)thiophene;4-Bromo-2-thiophenecarboxylic acid methyl ester;Methyl 4-bromothiophene-2-carboxylate;4-bromothiophene-2-carboxylic acid methyl ester;methyl 4-chlorothiophene-2-carboxylate;Methyl 4-broMothiophene-2...;2-Thiophenecarboxylic acid, 4-broMo-, Methyl ester;4-broMothiophene-2-carboxylate
• CAS NO: 62224-16-2
• Molecular Formula: C₆H₅BrO₂S
• Molecular Weight: 221.07
• Product Categories: API intermediates
• Mol File: 62224-16-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 255 °C
• Flash Point: 108 °C
• Appearance: /
• Density: 1.662
• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 4-bromothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-bromothiophene-2-carboxylate(62224-16-2)
• EPA Substance Registry System: Methyl 4-bromothiophene-2-carboxylate(62224-16-2)

Safety Data

• Hazardous Substances Data: 62224-16-2(Hazardous Substances Data)

Usage

General Description

Methyl 4-bromothiophene-2-carboxylate is a chemical compound with the molecular formula C8H7BrO2S. It is a ester derivative of 4-bromothiophene-2-carboxylic acid, which is a heterocyclic aromatic compound containing both sulfur and oxygen atoms in its structure. Methyl 4-bromothiophene-2-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It serves as a versatile building block in organic synthesis and has found applications in the development of new drugs and crop protection products. Additionally, it can be used in research laboratories as a reagent or substrate for various chemical reactions. Its unique structure and properties make it a valuable compound in the field of organic chemistry.

InChI:InChI=1/C6H5BrO2S/c1-9-6(8)5-2-4(7)3-10-5/h2-3H,1H3

Upstream product

• 872-31-1 3-Bromothiophene 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 16694-18-1 4-bromo-thiophene-2-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 6324-10-3 4,5-Dibromo-thiophene-2-carboxylic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 67-56-1 methanol 
• 58777-65-4 4-Bromothiophene-2-carboxylic acid chloride 

Downstream Products

• 887911-68-4 3-(5-(4-cyclopropyl-2-imino-1-methyl-5-oxoimidazolidin-4-yl)thiophen-3-yl)benzonitrile 
• 721960-44-7 4-bromo-N-methoxy-N-methylthiophene-2-carboxamide 
• 2613385-91-2 methyl 4-(dimethylphosphoryl)thiophene-2-carboxylate 
• 2361957-75-5 4-(dimethylphosphoryl)thiophene-2-carboxylic acid 

Relevant articles and documents

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor

We discovered 6-substituted thieno[2,3-d]pyrimidine compounds (3–9) with 3–4 bridge carbons and side-chain thiophene or furan rings for dual targeting one-carbon (C1) metabolism in folate receptor- (FR) expressing cancers. Synthesis involved nine steps st

Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives

CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.

Substituted quinolinone inhibitor

The invention provides a substituted quinolinone inhibitor and relates to a compound as shown in a formula (II) which is described in the specification or a pharmaceutically acceptable salt, solvate,active metabolite, polymorphic substance, ester, isomer or prodrug thereof, a pharmaceutical composition containing the compound as shown in the formula (II), and application of the compound and the pharmaceutical composition to treatment of diseases related to abnormal TOPK activity.