62242-95-9

Basic information

• Product Name: Benzoyl chloride, 2-amino-4-nitro-
• Synonyms: Benzoyl chloride,2-amino-4-nitro
• CAS NO: 62242-95-9
• Molecular Formula: C7H5ClN2O3
• Molecular Weight: 200.581
• Mol File: 62242-95-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-amino-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-amino-4-nitro-(62242-95-9)
• EPA Substance Registry System: Benzoyl chloride, 2-amino-4-nitro-(62242-95-9)

Safety Data

• Hazardous Substances Data: 62242-95-9(Hazardous Substances Data)

Upstream product

• 619-17-0 4-Nitroanthranilic acid 

Downstream Products

• 31930-18-4 2-amino-4-nitrobenzamide 
• 1220631-25-3 (2-amino-4-nitrophenyl)(4-methylpiperazin-1-yl)methanone 
• 251643-50-2 N-[2-(N,N-Dimethylamino)ethyl] 4-(N-methyl-N-{2-[N-methyl-N-(tert-butoxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetamide 
• 251643-40-0 4-(N-Methyl-N-{2-[N-methyl-N-(tert-butyloxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetic acid 
• 251643-31-9 Methyl 4-(N-methyl-N-{2-[N-methyl-N-(tert-butyloxycarbonyl)amino]-4-nitrobenzyloxycarbonyl}amino)phenylacetate 
• 251643-11-5 Methyl 2-[N-methyl-N-(tert-butyloxycarbonyl)amino]-4-nitrobenzoate 
• 251643-12-6 2-[N-Methyl-N-(tert-butyloxycarbonyl)amino]-4-nitrobenzoic acid 
• 251643-07-9 2-[N-Methyl-N-(tert-butyloxycarbonyl)amino]-4-nitrobenzyl alcohol 
• 3558-13-2 4-nitro-2-methylaminobenzoic acid methyl ester 
• 87376-25-8 2-amino-4-nitro-benzonitrile 
• 3558-19-8 methyl 2-amino-4-nitrobenzoate 

Relevant articles and documents

IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives

Continuing our work on tetracyclic tacrine analogues, we synthesized a series of acetylcholinesterase (AChE) inhibitors of 11H-indeno-[1,2-b]-quinolin-10-ylaminic structure. Selected substituents were placed in synthetically accessible positions of the tetracyclic nucleus, in order to explore the structure-activity relationships (SAR) and the mode of action of this class of anticholinesterases. A molecular modeling investigation of the binding interaction of the lead compound (1a) with the AChE active site was performed, from which it resulted that, despite the rather wide and rigid structure of 1a, there may still be the possibility to introduce some small substituent in some positions of the tetracycle. However, from the examination of the experimental IC50 values, it derived that the indenoquinoline nucleus probably represents the maximum allowable molecular size for rigid compounds binding to AChE. In fact, only a fluorine atom in position 2 maintains the AChE inhibitory potency of the parent compound, and, actually, increases the AChE-selectivity with respect to the butyrylcholinesterase inhibition. By studying the kinetics of AChE inhibition for two representative compounds of the series, it resulted that the lead compound (1a) shows an inhibition of mixed type, binding to both the active and the peripheral sites, while the more sterically hindered analogue 2nScheme 1Reagents: (a) ZnCl2 reflux; (b) (1) benzaldehyde reflux, (2) NaBH4. seems to interact only at the external binding site of the enzyme. This finding seems particularly important in the context of Alzheimer's disease research in the light of recent observations showing that peripheral AChE inhibitors might decrease the aggregating effects of the enzyme on the β-amyloid peptide (βA). Copyright (C) 2000 Elsevier Science Ltd.