622835-93-2

Basic information

• Product Name: Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate
• Synonyms: Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate;Methyl (2R)-2-bromo-2-(2-chlorophenyl)acetate
• CAS NO: 622835-93-2
• Molecular Formula: C9H8BrClO2
• Molecular Weight: 263.52
• Mol File: 622835-93-2.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 281 ºC
• Flash Point: 124 ºC
• Appearance: /
• Density: 1.567
• Refractive Index: 1.565
• CAS DataBase Reference: Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate(622835-93-2)
• EPA Substance Registry System: Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate(622835-93-2)

Safety Data

• Hazardous Substances Data: 622835-93-2(Hazardous Substances Data)

Usage

General Description

Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate is a chemical compound commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its ability to act as a mild acylating agent, and its unique chemical structure allows it to participate in a variety of organic reactions. Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate is also a versatile building block for the production of fine chemicals, and it is often used in the pharmaceutical industry for the creation of various drugs. Its properties make it a valuable tool for organic chemists and researchers in the development of new compounds and materials.

InChI:InChI=1/C9H8BrClO2/c1-13-9(12)8(10)6-4-2-3-5-7(6)11/h2-5,8H,1H3/t8-/m1/s1

Upstream product

• 10421-85-9 2-chloromandelic acid 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 141109-25-3 (S)-(+)-2-bromo-2-(2-chlorophenyl)acetic acid 
• 67-56-1 methanol 
• 89-98-5 2-chloro-benzaldehyde 
• 85259-19-4 methyl 2-bromo-2-(2-chlorophenyl)acetate 
• 101-41-7 benzeneacetic acid methyl ester 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 138647-05-9 2-bromo-2-(2-chlorophenyl)acetyl chloride 

Relevant articles and documents

Method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling aqueous solution method

The invention provides a method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling an aqueous solution method. According to the method, o-chlorophenylacetic acid is adopted as a main raw material, an organic solvent and water in an appropriate proportion are optimized to serve as a bromination mixed solvent, a two-phase reaction mode is adopted in the reaction process, a bromine-containing wastewater solution can be reused without complex treatment, a target product is prepared through bromination and esterification reactions, and the yield reaches78% or above; the method provided by the invention is based on a technical scheme of recycling an aqueous solution containing a bromination reagent. In the process production process, the input amountof a new bromination reagent is reduced to a great extent, the bromine atom utilization rate of the bromination reagent is increased, the problems of wastewater treatment and discharge are reduced, the pressure of environmental pollution is reduced, meanwhile, the reaction conditions are relatively mild, treatment is simple, and industrial production is facilitated.

COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as tocompositions and ophthalmic devices comprising such compounds.

Synthesis method of clopidogrel hydrogen sulfate

The invention discloses a synthesis method of clopidogrel hydrogen sulfate. The synthesis method takes o-phenylphthalic chloroacetic acid and 4,5,6,7tetrahydrothiophene[3,2-c] as raw materials and comprises the following steps: (1) carrying out acylation reaction; (2) carrying out bromination reaction; (3) carrying out esterification reaction; (4) preparing a clopidogrel base crude product; (5) extracting clopidogrel base; (5) carrying out racemic racemate reductionresolution; (7) preparing the clopidogrel hydrogen sulfate. According to the synthesis method of the clopidogrel hydrogen sulfate, disclosed by the invention, reasonable raw material selection and process route design are carried out, so that on one hand, a process flow is simplified and synthesis operation is easy to realize; on the other hand, reaction conditions are reduced, the reaction conditions are moderate and the method is easily smoothly carried out; the obtained finished product clopidogrel hydrogen sulfate has high yield and good quality; industrial production is easy to realize and a market prospect is wide.