62312-82-7

Basic information

• Product Name: Methanesulfonamide, N-[5-acetyl-2-(phenylmethoxy)phenyl]-N-(phenylmethyl)-
• CAS NO: 62312-82-7
• Molecular Formula: C23H23NO4S
• Molecular Weight: 409.506
• Mol File: 62312-82-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanesulfonamide, N-[5-acetyl-2-(phenylmethoxy)phenyl]-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide, N-[5-acetyl-2-(phenylmethoxy)phenyl]-N-(phenylmethyl)-(62312-82-7)
• EPA Substance Registry System: Methanesulfonamide, N-[5-acetyl-2-(phenylmethoxy)phenyl]-N-(phenylmethyl)-(62312-82-7)

Safety Data

• Hazardous Substances Data: 62312-82-7(Hazardous Substances Data)

Upstream product

• 14347-08-1 1-[4-Phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanone 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 62312-84-9 4-Benzyloxy-3-(N-methylsulphonyl-N-benzylamino)phenyl acetate 
• 686351-31-5 N-{5-(bromoacetyl)-2-[(phenylmethyl)oxy]phenyl}-N-(phenylmethyl)methanesulfonamide 
• 62312-86-1 N-benzyl-N-(2-benzoxy-5-hydroxy-phenyl)-methanesulfonamide 

Relevant articles and documents

METHOD FOR IMPROVING THE SOLUBILITY OF TRICYCLIC AMINO ALCOHOL DERIVATIVES

Compounds useful for treating and preventing diabetes, obesity, hyperlipidemia and so on are provided in the form of oral preparations exhibiting good absorbability in the digestive tract. A method for improving the solubility of tricyclic amino alcohol d

Adrenergic agents. 4. Substituted phenoxypropanolamine derivatives as potential β adrenergic agonists

A series of 1-(substituted phenoxy)-3-(tert-butylamino)-2-propanols in which the ring substituents were 3,4-dihydroxy (6f), 3- and 4-hydroxy (6g and 6h, respectively), 3-hydroxy-4-methylsulfonamido (6i), its 3,4-transposed isomer (6j), and 4-methylsulfonylmethyl (6k) was prepared and examined for β-adrenergic agonist and/or antagonist properties. Two of these compounds, 6f and 6j, were potent β-adrenoreceptor agonists in in vitro tests that measure a compound's ability to relax guinea pig tracheal smooth muscle and to increase the rate of contraction of guinea pig right atria. Several compounds had a dose-dependent effect. Although they produced potent β-adrenergic agonist activity at low concentrations, 6g, 6h, and 6j antagonized the effect of a standard β-adrenoreceptor agonist at higher concentrations. The methylsulfonylmethyl derivative 6k produced β-adrenergic blocking effects as demonstrated by attenuation of isoproterenol-induced increases in the rate of contraction of an isolated rabbit heart preparation. On the basis of these pharmacological results, coupled with NMR spectral data, it appears that the previous suggestion that aryloxypropanolamines interact with β-adrenoreceptors as a consequence of their ability to assume an orientation in which the benzene ring and ethanolamine moieties can be superimposed on those of corresponding adrenergic phenylethanolamines is invalid. An alternative 'bicyclic' rigid conformation involving two intramolecular hydrogen bonds in the protonated form of the aryloxypropanolamines is suggested to account for the similar β-adrenoreceptor activity of these compounds and related phenylethanolamines.