62314-69-6

Basic information

• Product Name: (7S,8S)-7,8,9,10-Tetrahydro-benzo[def]chrysene-7,8-diol
• CAS NO: 62314-69-6
• Molecular Weight: 288.346
• Mol File: 62314-69-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (7S,8S)-7,8,9,10-Tetrahydro-benzo[def]chrysene-7,8-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (7S,8S)-7,8,9,10-Tetrahydro-benzo[def]chrysene-7,8-diol(62314-69-6)
• EPA Substance Registry System: (7S,8S)-7,8,9,10-Tetrahydro-benzo[def]chrysene-7,8-diol(62314-69-6)

Safety Data

• Hazardous Substances Data: 62314-69-6(Hazardous Substances Data)

Upstream product

• 68906-75-2 (7R,8S)-7,8-epoxy-7,8,9,10-tetrahydrobenzopyrene 
• 37994-80-2 7,8-dihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 36504-67-3 7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene 

Downstream Products

• 63268-35-9 trans-(7S,8S)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene 

Relevant articles and documents

Resolution of polycyclic aromatic hydrocarbon dihydrodiols via diastereomeric formaldehyde acetals

Diastereomeric formaldehyde acetals, formed from the reaction of racemic benzo[a]pyrene dihydrodiol and (-)-chloromethylmenthyl ether, are novel intermediates for effecting the convenient resolution of these metabolites by HPLC. This resolution technique seems generally applicable since the dihydrodiols of benzo[c]phenanthrene can also be readily resolved through this methodology. Key differences in the proton NMR spectra of the diastereomeric dihydrodiol menthyloxymethyl ethers have been identified which could be used for absolute stereochemical assignments.

Enantioselective synthesis of the tumorigenic anti-diol epoxide metabolites of benzo[a]pyrene

Efficient, highly enantioselective syntheses of (+) and (-)-anti-benzo[a]pyrene diol epoxide (BPDE) from 9,10-dihydrobenzo[a]pyrene are described. Initial epoxidation catalyzed by (salen) Mn(III) complex gives 7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (