62322-82-1Relevant articles and documents
Identification of degradation products from epinephrine (adrenalin) in infusion solutions by HPLC and multidetection
Baran,Schwedt
, p. 273 - 275 (2007/10/02)
The degradation products of epinephrine (adrenalin) standard solutions were separated reversed phase chromatographical and collected by multidetection. For that purpose was used a UV diode array, a fluorescence and a electrochemical detector in series connection. Besides adrenalin, eight further degradation products could be recognized. For the identification of separated intermediates i.a. UV absorption spectra and hydrodynamic voltammogrammes were brought in. The operating system was put in for the analysis of an aged adrenaline injection solution, stabilized by sodium bisulfite. Rapid statements about the content of the active substance and the direction of degradation, also in the presence of stabilizers, were possible.