62351-29-5

Basic information

• Product Name: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, (2-oxo-1-pyrrolidinyl)methyl ester
• CAS NO: 62351-29-5
• Molecular Formula: C21H25N3O5S
• Molecular Weight: 431.513
• Mol File: 62351-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, (2-oxo-1-pyrrolidinyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, (2-oxo-1-pyrrolidinyl)methyl ester(62351-29-5)
• EPA Substance Registry System: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, (2-oxo-1-pyrrolidinyl)methyl ester(62351-29-5)

Safety Data

• Hazardous Substances Data: 62351-29-5(Hazardous Substances Data)

Upstream product

• 31282-95-8 1-(chloromethyl)pyrrolidin-2-one 
• 69-57-8 Penicillin G sodium 

Downstream Products

• 15438-71-8 1-(hydroxymethyl)-2-pyrrolidinone 
• 61-33-6 penicillin G 

Relevant articles and documents

A New Direct Synthesis of Tertiary N-Acyloxymethylamide Prodrugs of Carboxylic Acid Drugs

N-Alkyl-N-chloromethylamides 2, prepared from secondary amides, paraformaldehyde and chlorotrimethylsilane, react readily with carboxylate anions to generate the corresponding tertiary N-acyloxymethylamides 3 in good yield; the latter give rise to the parent carboxylic acids in aqueous media at pH 7.4 and 37 deg C with half-lives between ca. 1 min and 42 h.