62354-43-2

Basic information

• Product Name: D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE
• Synonyms: D-Valyl-L-leucyl-N-(4-nitrophenyl)-L-lysinamide dihydrochloride;H-D-Val-LK-pNA;H-D-VAL-LEU-LYS-PNA 2 HCL;D-VAL-LEU-LYS-PNA 2HCL;D-VAL-LEU-LYS-PNA DIHYDROCHLORIDE;D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE;D-VALYL-L-LEUCYL-L-LYSINE-4-NITROANILIDE 2HCL;D-VALYL-L-LEUCYL-L-LYSINE 4-NITROANILIDE DIHYDROCHLORIDE
• CAS NO: 62354-43-2
• Molecular Formula: C23H40Cl2N6O5
• Molecular Weight: 551.51
• Product Categories: Activity;Chromogenic;Enzyme Substrates
• Mol File: 62354-43-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 454.5°Cat760mmHg
• Flash Point: 228.7°C
• Appearance: /
• Density: 1.226g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE(62354-43-2)
• EPA Substance Registry System: D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE(62354-43-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-63
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 62354-43-2(Hazardous Substances Data)

Usage

Description

D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE is a synthetic peptide compound that serves as a chromogenic substrate in various biochemical assays. It is composed of the amino acid sequence D-valine, leucine, and lysine, with a p-nitroanilide group attached. D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE is particularly useful in the study and analysis of proteolytic enzyme activity, specifically in amidolytic and plasminogen activating assays.

Uses

Used in Biochemical Research:
D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE is used as a chromogenic substrate for assessing the amidolytic activity of proteolytic enzymes. D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE's p-nitroanilide group allows for the colorimetric detection of enzyme activity, providing a quantitative measure of enzyme function.
Used in Plasminogen Activation Assays:
In the field of hemostasis and fibrinolysis research, D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE is used as a specific substrate to determine the formation of plasmin from plasminogen. This is crucial for understanding the regulation of blood clot formation and dissolution, as well as the role of plasminogen activators in these processes.
Used in Pharmaceutical Development:
D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE can be employed in the development of drugs targeting proteolytic enzymes or plasminogen activation. By using this substrate in assays, researchers can screen for potential drug candidates that modulate enzyme activity or influence plasmin formation, leading to the discovery of new therapeutic agents for various medical conditions.
Used in Diagnostic Applications:
D-VAL-LEU-LYS P-NITROANILIDE DIHYDROCHLORIDE can also be utilized in diagnostic assays to detect and monitor the activity of proteolytic enzymes or the presence of plasmin in biological samples. This can be particularly useful in clinical settings for the diagnosis and monitoring of conditions related to abnormal blood clotting or fibrinolysis.