623950-04-9

Basic information

• Product Name: 4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester
• Synonyms: 4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester
• CAS NO: 623950-04-9
• Molecular Weight: 351.4
• Mol File: 623950-04-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester(623950-04-9)
• EPA Substance Registry System: 4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester(623950-04-9)

Safety Data

• Hazardous Substances Data: 623950-04-9(Hazardous Substances Data)

Upstream product

• 1048677-11-7 4-iodo-3,5-dimethylbenzoic acid 
• 1048677-12-8 benzyl 4-iodo-3,5-dimethylbenzoate 
• 137650-15-8 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoate 
• 623950-03-8 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 623950-02-7 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid 
• 861676-20-2 4'-ethylcarbamoyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester 
• 861676-19-9 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate 
• 861676-21-3 4'-morpholinylcarbonyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester 
• 623950-05-0 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoate 

Relevant articles and documents

Novel method for preparing iludoline intermediate

The invention discloses a preparation method of a pharmaceutical intermediate, 4-(aminocarbonyl)-N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine methyl ester, for treating irritable bowel syndrome (IBS-D). The preparation method comprises the following steps: with 4-iodine-3,5-dimethyl benzoic acid as a raw material, protecting carboxyl through a group, carrying out Negishi couplingreaction under the catalysis of Pd2(dba)3, removing the carboxyl protecting group, and forming active ester to react with ammonia water, thereby obtaining the product. The invention provides a novel synthetic route for a drug intermediate for treating irritable bowel syndrome (IBS-D); the reaction conditions are easy to control, the post-treatment operation is simple, and industrial production canbe smoothly realized.

A convenient, large-scale synthesis of 4′-carboxamido N-Boc-2′,6′-dimethyl-l-phenylalanines

A large-scale synthesis of a series of 4′-carboxamido N-Boc-2′,6′-dimethyl-l-phenylalanines is described. This method features mild reaction conditions and high chemical yields from commercially available N-Boc-2′,6′-dimethyl-l-tyrosine methyl ester.

Novel compounds as opioid receptor modulators

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.