62457-35-6Relevant articles and documents
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Wright,Du Puis
, p. 1303,1304 (1946)
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Acid-mediated intramolecular cationic cyclization using an oxygen atom as internal nucleophile: Synthesis of substituted oxazolo-, oxazino- and oxazepinoisoindolinones
Sikoraiová, Jana,Marchalín, ?tefan,Da?ch, Adam,Decroix, Bernard
, p. 4747 - 4751 (2007/10/03)
Efficient assembly of substituted oxazolo-, oxazino-, and oxazepinoisoindolinones (5-7, 12-15 and 19) is described in three steps according to an acidic α-oxoamidoalkylation reaction from ready available phthalic anhydride by successive imidation, sodium borohydride reduction and intramolecular cationic cyclization involving N-acyliminium species. The relative stereochemistry accompanying these reactions was also discussed.
N-[(1,4-DIAZABICYCLO[2.2.2] OCT-2-YL)METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATIONS AND THEIR APPLICATION IN THERAPEUTICS
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, (2008/06/13)
An optically active isomer or a racemate of a compound of general formula (I) STR1 in which either R 1 represents a methoxy or cyclopropylmethoxy group andR 2 represents a hydrogen, chlorine or bromine atom, orR 1 and R 2 together form, and in this order, a group of formula--O--CH 2--O--,--O--(CH 2) 2--,--O--(CH 2) 2--O--or--O--(CH 2) 3--O--,R 3 represents a hydrogen atom or an amino group, andR 4 represents a hydrogen, chlorine or bromine atom,in the form of a free base or of a pharmaceutically acceptable acid addition salt.