62460-63-3

Basic information

• Product Name: 4H-3,1-Benzoxazine, 2-(4-methoxyphenyl)-
• CAS NO: 62460-63-3
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol File: 62460-63-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-3,1-Benzoxazine, 2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-3,1-Benzoxazine, 2-(4-methoxyphenyl)-(62460-63-3)
• EPA Substance Registry System: 4H-3,1-Benzoxazine, 2-(4-methoxyphenyl)-(62460-63-3)

Safety Data

• Hazardous Substances Data: 62460-63-3(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 100-07-2 4-methoxy-benzoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 82085-87-8 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine 

Downstream Products

• 18600-55-0 2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

CuCl/DABCO/4-HO-TEMPO-catalyzed aerobic oxidative synthesis of 2-substituted quinazolines and 4 H -3,1-benzoxazines

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.

Highly efficient one-pot synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines via cross dehydrogenative coupling using sodium hypochlorite

This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.