62495-36-7

Basic information

• Product Name: Methanone, (2-hydroxy-4-methoxyphenyl)(2-methoxyphenyl)-
• Synonyms: 2-Hydroxy-2',4-dimethoxybenzophenon;2-hydroxy-4-methoxyphenyl 2-methoxyphenyl ketone;2',4-dimethoxy-2-hydroxybenzophenone;2-hydroxy-4-methoxy-2'-methoxybenzophenone;2-hydroxy-2',4-dimethoxybenzophenone
• CAS NO: 62495-36-7
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• Mol File: 62495-36-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 92–93°C
• CAS DataBase Reference: Methanone, (2-hydroxy-4-methoxyphenyl)(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-hydroxy-4-methoxyphenyl)(2-methoxyphenyl)-(62495-36-7)
• EPA Substance Registry System: Methanone, (2-hydroxy-4-methoxyphenyl)(2-methoxyphenyl)-(62495-36-7)

Safety Data

• Hazardous Substances Data: 62495-36-7(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of o-anisic acid with m-methoxy-phenol in the presence of zinc chloride and phosphorous oxychloride at 65–70° for 2 h (68%).

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 529-28-2 4-iodoanisol 
• 108-46-3 recorcinol 
• 79204-61-8 2-Methoxy-benzoic acid 5-methoxy-2-(2-methoxy-benzoyl)-phenyl ester 
• 79204-57-2 2,3-bis(o-methoxyphenyl)-6-hydroxybenzofuran 
• 79204-58-3 6-Methoxy-2,3-bis(o-methoxyphenyl)benzofuran 
• 6706-96-3 2,2'-dimethoxybenzoin 
• 33077-87-1 2,2',4-trimethoxybenzophenone 

Downstream Products

• 1542744-00-2 N-((1S,2R)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide 
• 3722-51-8 3-hydroxyxanthen-9-one 
• 1542743-74-7 (R)-2-((9-oxo-9H-xanthen-3-yl)oxy)-N-(1-(p-tolyl)ethyl)acetamide 
• 1542743-76-9 (S)-2-((9-oxo-9H-xanthen-3-yl)oxy)-N-(1-(p-tolyl)ethyl)acetamide 
• 1262893-91-3 (R)-N-(2-hydroxy-1-phenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide 
• 1379779-05-1 (S)-N-(2-hydroxy-1-phenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide 
• 1542743-98-5 N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-2-((9-oxo-9H-xanthen-3-yl)oxy)acetamide 
• 3113-23-3 2-(2-methoxybenzoyl)-5-methoxy-1,4-benzoquinone 
• 42833-90-9 (2,5-Dihydroxy-4-methoxy-phenyl)-(2-methoxy-phenyl)-methanone 
• 33077-87-1 2,2',4-trimethoxybenzophenone 
• 93097-69-9 7-methoxy-4-(2-methoxyphenyl)-3-phenylcoumarin 

Relevant articles and documents

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides

A rhodium-catalyzed general protocol for the directing-group-assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy- or amino-group-directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2-hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo- and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3-salicyloylpyridines in high yields.

Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS

In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.