625095-60-5 Usage
Description
Pradefovir, also known as Adefovir dipivoxil, is a prodrug that is converted to Adefovir, an antiviral medication, within the body. It is specifically designed to target the liver, making it a valuable compound in the treatment of hepatitis B. Pradefovir demonstrates its effectiveness by inhibiting viral replication and reducing the viral load in patients, thus helping to manage and control the disease.
Uses
Used in Antiviral Applications:
Pradefovir is used as an antiviral agent for the treatment of chronic hepatitis B infection. It works by targeting the liver and converting to Adefovir, which then inhibits the replication of the hepatitis B virus, reducing the viral load and helping to prevent further liver damage.
Used in Hepatitis B Treatment:
In the medical industry, pradefovir is used as a prodrug for the targeted delivery of Adefovir to the liver. This targeted approach is crucial for the treatment of hepatitis B, as it allows for a more focused and effective treatment strategy. By concentrating the medication in the liver, where the hepatitis B virus is most active, pradefovir helps to minimize the potential side effects and improve the overall efficacy of the treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 625095-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,5,0,9 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 625095-60:
(8*6)+(7*2)+(6*5)+(5*0)+(4*9)+(3*5)+(2*6)+(1*0)=155
155 % 10 = 5
So 625095-60-5 is a valid CAS Registry Number.
625095-60-5Relevant articles and documents
Pradefovir: A prodrug that targets adefovir to the liver for the treatment of hepatitis B
Reddy, K. Raja,Matelich, Michael C.,Ugarkar, Bheemarao G.,Gómez-Galeno, Jorge E.,DaRe, Jay,Ollis, Kristin,Sun, Zhili,Craigo, William,Colby, Timothy J.,Fujitaki, James M.,Boyer, Serge H.,Van Poelje, Paul D.,Erion, Mark D.
, p. 666 - 676 (2008/09/19)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with the r
Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver
Erion, Mark D.,Reddy, K. Raja,Boyer, Serge H.,Matelich, Michael C.,Gomez-Galeno, Jorge,Lemus, Robert H.,Ugarkar, Bheemarao G.,Colby, Timothy J.,Schanzer, Juergen,Van Poelje, Paul D.
, p. 5154 - 5163 (2007/10/03)
A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, is described that combines properties of rapid liver cleavage with high plasma and tissue stability to achieve increased drug levels in the liver. The prodrugs are substituted c
Novel phosphonic acid based prodrugs of PMEA and its analogues
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Page 22, (2010/11/30)
Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: 1wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmet
