625110-87-4Relevant articles and documents
Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity
Taylor, Dennis K.,Avery, Thomas D.,Greatrex, Ben W.,Tiekink, Edward R. T.,Macreadie, Ian G.,Macreadie, Peter I.,Humphries, Adam D.,Kalkanidis, Martha,Fox, Emma N.,Klonis, Nectarios,Tilley, Leann
, p. 1833 - 1839 (2004)
We report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium falciparum in vitro. Structure-act