62551-73-9Relevant articles and documents
Non-Bonding 1,4-Sulphur-Oxygen Interaction Governs the Reactivity of α-Ketothioesters in Triphenylphosphine-Catalyzed Cyclization with Acetylenedicarboxylates
Bankura, Abhijit,Saha, Jayanta,Maity, Rajib,Das, Indrajit
supporting information, p. 1014 - 1021 (2020/12/31)
α-Ketothioesters undergo triphenylphosphine (PPh3)-catalyzed cyclization with acetylenedicarboxylate esters smoothly, in contrast to α-ketooxoesters which require more drastic conditions with the limited substrate scope. The reaction works well
N-Heterocyclic Carbene-Catalyzed Umpolung of Alkynyl 1,2-Diketones
Kong, Xiangwen,Zhang, Guoxiang,Yang, Shuang,Liu, Xiaozhi,Fang, Xinqiang
, p. 2729 - 2734 (2017/08/23)
The umpolung of alkynyl 1,2-diketones via N-heterocyclic carbene (NHC) catalysis was achieved for the first time, allowing the rapid access to a large variety of synthetically and pharmaceutically important α-pyrones under very mild conditions. A completely new NHC-catalyzed umpolung pattern involving an O-acylated allenolate as the key intermediate was proposed. Moreover, an unprecedented reaction pathway, featured by a series of group migrations and new bond formation, was postulated to demonstrate the formation of the products. (Figure presented.).
C?H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery
Nicolle, Simon M.,Nortcliffe, Andrew,Bartrum, Hannah E.,Lewis, William,Hayes, Christopher J.,Moody, Christopher J.
supporting information, p. 13623 - 13627 (2017/09/13)
A new route to spiro-oxetanes, potential scaffolds for drug discovery, is described. The route is based on the selective 1,4-C?H insertion reactions of metallocarbenes, generated from simple carbonyl precursors in flow or batch mode, to give spiro-β-lacto
