62568-57-4 Usage
Description
Delta-sleep-inducing peptide (DSIP), also known as Emideltide, is a neuropeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and a molecular mass of 848.81 g/mol. It is found in neurons, peripheral organs, and plasma, and is known for its ability to induce delta sleep in mammals. DSIP also affects electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs, including their withdrawal.
Uses
Used in Sleep Promotion:
DSIP is used as a sleep-promoting agent for its ability to induce delta sleep in mammals. It helps relieve stress and aches that keep individuals from achieving restful sleep.
Used in Pain and Stress Management:
DSIP is used as a treatment for poor sleep, pain conditions, and stress-related symptoms due to its natural sleep-promoting and stress-relieving properties.
Used in Research:
Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound for studying the effects of DSIP on sleep, stress, and other related functions.
Used in the Treatment of Various Conditions:
DSIP is used as a therapeutic agent for various conditions, including sleep disorders, stress-related issues, and pain management, due to its multiple beneficial functions.
benefits
Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production.
Physiological effects
Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep.
Check Digit Verification of cas no
The CAS Registry Mumber 62568-57-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,5,6 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 62568-57:
(7*6)+(6*2)+(5*5)+(4*6)+(3*8)+(2*5)+(1*7)=144
144 % 10 = 4
So 62568-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)
62568-57-4Relevant articles and documents
Antioxidant and detoxifying activities of analogues of the delta sleep inducing peptide
Mikhaleva,Ivanov,Onoprienko,Prudchenko,Chikin,Yakubovskaya,Nemtsova,Bezborodova
, p. 1 - 8 (2014)
Sixteen peptides differing in structure from the delta sleep inducing peptide (DSIP) by one to two substitutions of amino acid residues have been synthesized to study the possibility of their application in oncology. The antioxidant properties of the peptides in vitro and their detoxifying activity in vivo have been examined on a model of toxicosis caused by cisplatin, a cytostatic drug widely used in the therapy of tumor diseases. It has been shown that almost all DSIP analogues examined exhibit a direct antioxidant activity, with the activity of the ID-6 analogue being higher than that of DSIP and comparable with that of vitamin C and β-carotene. This analogue shows the most pronounced detoxifying activity toward the action of cisplatin, which manifests itself as a decrease in the death of animals from acute toxicity to 17% compared to 50-67% in the control and the restoration of some biochemical parameters of blood, in particular, a decrease in the activity of the enzymes, aspartate and alanine aminotransferases, and the concentration of the end products of nitrogen exchange: creatinine and urea. Thus, the peptides of the DSIP family may appear promising agents for decreasing the toxic effects of cytostatics used in oncology.
NATURAL PEPTIDES AND THEIR ANALOGS. XXXIV. SYNTHESIS OF DELTA-PEPTIDE AND ITS STRUCTURAL ANALOGS
Ryabtsev, M. N.,Funtova, S. M.,Zuyanova, T. I.,Shvachkin, Yu. P.
, p. 394 - 399 (2007/10/02)
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SYNTHESIS OF THE δ-SLEEP PEPTIDE AND SOME OF ITS ANALOGS
Kalikhevich, V. N.,Churkina, S. I.,Martynov, V. F.
, p. 1690 - 1695 (2007/10/02)
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