625853-74-9

Basic information

• Product Name: 5-Hydroxy Pioglitazone
• Synonyms: 5-Hydroxy Pioglitazone Discontinued;Pioglitazone EP IMpurity A;5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]Methyl]-5-hydroxy-;Pioglitazone IMpurity A (5-Hydroxy Pioglitazone);Pioglitazone EP Impurity;5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-5-hydroxy-2,4-thiazolidinedione;5-Hydroxy Pioglitazone;Pioglitazone Impurity A(EP)
• CAS NO: 625853-74-9
• Molecular Formula: C19H20N2O4S
• Molecular Weight: 372.44
• Product Categories: Pharmaceuticals;Sulfur & Selenium Compounds;Intermediates & Fine Chemicals;Metabolites & Impurities
• Mol File: 625853-74-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 615.2°C at 760 mmHg
• Flash Point: 325.9°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 5.4E-16mmHg at 25°C
• Refractive Index: 1.635
• PKA: 5.36±0.50(Predicted)
• CAS DataBase Reference: 5-Hydroxy Pioglitazone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxy Pioglitazone(625853-74-9)
• EPA Substance Registry System: 5-Hydroxy Pioglitazone(625853-74-9)

Safety Data

• Hazardous Substances Data: 625853-74-9(Hazardous Substances Data)

Usage

Description

5-Hydroxy Pioglitazone is a novel metabolite of Pioglitazone (P471000), which is a member of the thiazolidinedione class of antidiabetic drugs. It is derived from the parent compound Pioglitazone, which is used for the treatment of type 2 diabetes. The presence of a hydroxyl group in its structure distinguishes it from the original compound, potentially altering its pharmacological properties and applications.

Uses

Used in Pharmaceutical Industry:
5-Hydroxy Pioglitazone is used as a pharmaceutical compound for the development of new therapeutic agents. As a metabolite of Pioglitazone, it may exhibit different pharmacological effects and could be investigated for its potential in treating type 2 diabetes or other related conditions. Its unique structure may also provide insights into the optimization of antidiabetic drugs and the understanding of their metabolic pathways.
Used in Research and Development:
5-Hydroxy Pioglitazone is used as a research compound for studying the metabolic pathways and pharmacological effects of Pioglitazone. It can be utilized in various in vitro and in vivo experiments to explore its potential as a therapeutic agent, as well as to understand the mechanisms of action and side effects associated with Pioglitazone.
Used in Quality Control and Impurity Profiling:
5-Hydroxy Pioglitazone is used as an impurity reference standard for the quality control and impurity profiling of Pioglitazone. It helps in the identification, quantification, and control of impurities in the manufacturing process of Pioglitazone, ensuring the safety and efficacy of the final drug product.
Used in Drug Metabolism Studies:
5-Hydroxy Pioglitazone is used as a substrate in drug metabolism studies to investigate the metabolic pathways and enzyme interactions of Pioglitazone. This information is crucial for understanding the pharmacokinetics and pharmacodynamics of the drug, as well as for the development of personalized treatment strategies based on individual metabolic profiles.

InChI:InChI=1/C19H20N2O4S/c1-2-13-3-6-15(20-12-13)9-10-25-16-7-4-14(5-8-16)11-19(24)17(22)21-18(23)26-19/h3-8,12,24H,2,9-11H2,1H3,(H,21,22,23)