6259-08-1

Basic information

• Product Name: 5-CHLORO-2-METHOXY-4-NITROANILINE
• Synonyms: 5-CHLORO-2-METHOXY-4-NITROANILINE;5-chloro-4-nitro-o-anisidine;5-Chloro-2-methoxy-4-nitrobenzenamine;2-Amino-4-chloro-5-nitroanisole;2-Methoxy-4-nitro-5-chloroaniline;2-Amino-4-chloro-5-nitroanisole, 5-Chloro-4-nitro-o-anisidine, 4-Amino-2-chloro-5-methoxynitrobenzene
• CAS NO: 6259-08-1
• Molecular Formula: C₇H₇ClN₂O₃
• Molecular Weight: 202.6
• EINECS: 228-397-8
• Mol File: 6259-08-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 131 °C
• Boiling Point: 400.1°C at 760 mmHg
• Flash Point: 195.8°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 1.31E-06mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: 2-8°C
• PKA: -0.04±0.14(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-METHOXY-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHOXY-4-NITROANILINE(6259-08-1)
• EPA Substance Registry System: 5-CHLORO-2-METHOXY-4-NITROANILINE(6259-08-1)

Safety Data

• Hazardous Substances Data: 6259-08-1(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-METHOXY-4-NITROANILINE is a chemical compound with the molecular formula C7H7ClN2O3. It is an organic compound that contains a chloro, methoxy, and nitro group on a benzene ring. 5-CHLORO-2-METHOXY-4-NITROANILINE is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemical products. It is also used as a chemical building block in the production of dyes and pigments. 5-CHLORO-2-METHOXY-4-NITROANILINE is a yellow solid that is sparingly soluble in water but soluble in organic solvents. It is important to handle this compound with care as it may be harmful if ingested, inhaled, or in contact with skin and eyes.

InChI:InChI=1/C7H7ClN2O3/c1-13-7-3-6(10(11)12)4(8)2-5(7)9/h2-3H,9H2,1H3

Upstream product

• 6358-07-2 2-amino-4-chloro-5-nitrophenol 
• 74-88-4 methyl iodide 
• 92550-22-6 N,N'-bis-(5-chloro-2-methoxy-phenyl)-urea 
• 22521-37-5 N-acetyl-5-chloro-4-nitro-2-anisidine 

Downstream Products

• 99987-97-0 2-methoxy-5-morpholino-4-nitro-aniline 
• 500699-40-1 benzenesulfonic acid-(5-chloro-2-methoxy-4-nitro-anilide) 
• 886981-62-0 1-(5-chloro-2-methoxy-4-nitro-phenyl)-3-(5-cyano-pyrazin-2-yl)-urea 
• 886981-64-2 1-(4-amino-5-chloro-2-methoxy-phenyl)-3-(5-cyano-pyrazin-2-yl)-urea 

Relevant articles and documents

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Based on the X-ray crystallography of our lead compound 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea in the checkpoint kinase 1 (Chk1) enzyme, we modified R4, and to a lesser extent, R2, and R5 of the phenyl ring, and made a variety of N-aryl-N′-pyrazinylurea Chk1 inhibitors. Enzymatic activity less than 20 nM was observed in 15 of 41 compounds. Compound 8i provided the best overall results in the cellular assays as it abrogated doxorubicin-induced cell cycle arrest (IC50 = 1.7 μM) and enhanced doxorubicin cytotoxicity (IC50 = 0.44 μM) while displaying no single agent activity.

N-Substituted 2-methoxybenzenesulphonamides and medicaments containing them

The invention relates to new N-substituted benzenesulphonamides of general formula STR1 in which N IS 2 OR 3, R1 and R2 are hydrogen atoms, methyl, ethyl groups, or jointly form with the nitrogen a nitrogenized heterocyclic ring having 5 or 6 members, in particular a piperidino, pyrrolidino or morpholino group, R3 is a hydrogen atom, an NO2 group, an NH2 group, or a halogen, R4 is a hydrogen, a halogen, an NH2 group or a sulphonamide group. These compounds are useful as active substances of medicaments, in particular as antiemetic.