6262-23-3

Basic information

• Product Name: 4-methyl-N,N'-m-phenylenediformamide
• Synonyms: 2,4-diformamidotoluene;4-methyl-N,N'-m-phenylenediformamide;N,N'-diformyl-1,3-diamino-6-methylbenzene;N,N'-(4-Methyl-1,3-phenylene)bisformamide
• CAS NO: 6262-23-3
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.1879
• EINECS: 228-414-9
• Mol File: 6262-23-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 476.5°Cat760mmHg
• Flash Point: 223.7°C
• Appearance: /
• Density: 1.279g/cm³
• CAS DataBase Reference: 4-methyl-N,N'-m-phenylenediformamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N,N'-m-phenylenediformamide(6262-23-3)
• EPA Substance Registry System: 4-methyl-N,N'-m-phenylenediformamide(6262-23-3)

Safety Data

• Hazardous Substances Data: 6262-23-3(Hazardous Substances Data)

Usage

General Description

4-methyl-N,N'-m-phenylenediformamide is a chemical compound comprised of a formamide group and a methyl group attached to the 4-position of the phenylene ring. It is commonly used as a building block in the synthesis of various organic compounds and pharmaceuticals. This chemical has a molecular formula C9H10N2O and a molecular weight of 162.19 g/mol. It is a white crystalline solid that is moderately soluble in water and has a melting point of around 154-156°C. 4-methyl-N,N'-m-phenylenediformamide is primarily used in research and development labs for its role as an intermediate in organic synthesis and pharmaceutical production.

Upstream product

• 107-31-3 Methyl formate 
• 854701-62-5 N-(3-amino-4-methylphenyl)formamide 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 121-14-2 2,4-dinitrotoluene 
• 606-20-2 2,6-dinitrotoluene 
• 64-18-6 formic acid 

Relevant articles and documents

Chromium-catalysed efficient: N -formylation of amines with a recyclable polyoxometalate-supported green catalyst

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemoselectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

An efficient way for the: N -formylation of amines by inorganic-ligand supported iron catalysis

The first example of an inorganic-ligand supported iron(iii) catalysed coupling of formic acid and amines to form formamides is reported. The pure inorganic catalyst (NH4)3[FeMo6O18(OH)6] (1), which consists of a central FeIII single-atomic core supported within a cycle-shaped inorganic ligand consisting of six MoVIO6 octahedra, shows excellent activity and selectivity, and avoids the use of complicated/commercially unavailable organic ligands. Various primary amines and secondary amines have been successfully transformed into the corresponding formamides under mild conditions, and the formylation of primary diamines has also been achieved for the first time. The Fe catalyst 1 can be reused several times without appreciable loss of activity.

PROCESS FOR THE PREPARATION OF AROMATIC FORMAMIDES

The invention relates to a process for the preparation of formamides by reacting aromatic amines with a formic acid ester in the presence of a catalyst, wherein the catalyst is a phosphorus-containing acid or a Lewis-acidic metal salt.