62659-61-4Relevant articles and documents
3-FLUOROBENZODIAZEPINES
Middleton, W. J.,Bingham, E. M.,Smith, D. H.
, p. 557 - 572 (2007/10/02)
Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines.These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.
Process for the preparation of 3-fluorobenzodiazepines
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, (2008/06/13)
3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one, useful as tranquilizers, muscle relaxants, and sedatives.