6266-35-9

Basic information

• Product Name: 2-Chloropropylamine Hydrochloride
• Synonyms: Propylamine, 2-chloro-, hydrochloride; 2-chloropropan-1-amine hydrochloride (1:1); 2-Chloropropylamine?HCL
• CAS NO: 6266-35-9
• Molecular Formula: C₃H₈ClN*ClH
• Molecular Weight: 130.0163
• Mol File: 6266-35-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 115.6°C at 760 mmHg
• Flash Point: 23.7°C
• Vapor Pressure: 18.9mmHg at 25°C
• CAS DataBase Reference: 2-Chloropropylamine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropropylamine Hydrochloride(6266-35-9)
• EPA Substance Registry System: 2-Chloropropylamine Hydrochloride(6266-35-9)

Safety Data

• Hazardous Substances Data: 6266-35-9(Hazardous Substances Data)

Upstream product

• 78-96-6 3-amino-2-propanol 
• 75-55-8 2-Methylaziridine 

Downstream Products

• 2258-21-1 3-(2-methyl-1H-imidazol-1-yl)propan-1-amine 
• 391668-76-1 1-(3-[1,3]dioxolan-2-ylphenyl)azetidine 
• 285125-40-8 2-(2-methyl-4-nitrophenylimino)-5-methyl-1,3-thiazolidine 
• 591733-72-1 (4R,5S)-(+)-4-methyl-5-phenyloxazolidin 
• 1005-04-5 4-(2-amino-1-methylethyl)morpholine 
• 54151-70-1 1-(2-aminoisopropyl)-piperidine 
• 50998-07-7 2-Pyrrolidin-1-yl-propylamine 
• 29670-17-5 1-(4-chlorophenylthio)-2-propanamine hydrochloride 
• 104864-10-0 2-(4-chlorophenylthio)propanamine hydrochloride 

Relevant articles and documents

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity

Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.