626604-79-3

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-acetamide,1-ethyl-(9CI)
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-acetamide,1-ethyl-(9CI)
• CAS NO: 626604-79-3
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.24042
• Product Categories: ETHYL
• Mol File: 626604-79-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-acetamide,1-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-acetamide,1-ethyl-(9CI)(626604-79-3)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-acetamide,1-ethyl-(9CI)(626604-79-3)

Safety Data

• Hazardous Substances Data: 626604-79-3(Hazardous Substances Data)

Upstream product

• 169031-06-5 (1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-oxo-acetic acid methyl ester 
• 357263-49-1 methyl α-oxo-1H-pyrrolo[2,3-b]pyridine-3-acetate 
• 271-63-6 7-Azaindole 
• 169031-08-7 (1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester 

Relevant articles and documents

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides was synthesized and evaluated for activity against GSK-3β and selectivity versus PKC-βII, as well as a broad panel of protein kinases. Compounds 14 and 17c potently inhibited GSK-3β (IC50=7 and 26nM, respectively) and exhibited excellent selectivity over PKC-βII (325 and >385-fold, respectively). Compound 17c was also highly selective against 68 other protein kinases. In a cell-based functional assay, both 14 and 17c effectively increased glycogen synthase activity by inhibiting GSK-3β.