627-75-8 Usage
Description
D-(-)-Arginine hydrochloride is an amino acid derivative that occurs in two possible enantiomeric forms, D and L. It is structurally similar to L-arginine, but with the stereochemistry of its chiral center being opposite. D-(-)-Arginine hydrochloride is used in various applications across different industries due to its unique properties.
Uses
Used in Pharmaceutical Industry:
D-(-)-Arginine hydrochloride is used as a precursor in the synthesis of various pharmaceutical compounds. It is used for the production of D-arginyl ethyl ester, which is synthesized by stirring D-arginine monohydrochloride and excess anhydrous ethanol in an ice bath.
Used in Medical Research:
D-(-)-Arginine hydrochloride is used as a research compound to study its effects on creatinine metabolism. It has been found to cause slightly larger increases in muscle creatine, which can be useful in understanding the role of creatine in muscle function and metabolism.
Used in Cardiovascular Health:
D-(-)-Arginine hydrochloride is used as a therapeutic agent for cardiovascular health. It has been shown to attenuate increased arginase expression, oxidative stress, endothelial dysfunction, and advanced glycation endproducts formation induced by methylgloxyl and high glucose. This attenuation is thought to occur through an endothelial NOS independent mechanism, which can help improve cardiovascular health and reduce the risk of related complications.
Check Digit Verification of cas no
The CAS Registry Mumber 627-75-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 627-75:
(5*6)+(4*2)+(3*7)+(2*7)+(1*5)=78
78 % 10 = 8
So 627-75-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m1./s1
627-75-8Relevant articles and documents
Ruckerbactin Produced by Yersinia ruckeri YRB Is a Diastereomer of the Siderophore Trivanchrobactin Produced by Vibrio campbellii DS40M4
Butler, Alison,Dulaney, Kalana,Reitz, Zachary L.,Stow, Parker R.,Thomsen, Emil
, p. 264 - 269 (2022/01/15)
The Gram-negative bacterium Yersinia ruckeri is the causative agent for enteric red mouth disease in salmonids. The genome of Y. ruckeri YRB contains a biosynthetic gene cluster encoding the biosynthesis of catechol siderophores that are diastereomeric with the known vanchrobactin class of siderophores, (DHBDArgLSer)(1–3). Ruckerbactin (1), produced by Y. ruckeri YRB, was found to be the linear tris-l-serine ester composed of l-arginine and 2,3-dihydroxybenzoic acid, (DHBLArgLSer)3. The biscatechol, (DHBLArgLSer)2 (2), and monocatechol, DHBLArgLSer (3), compounds were also isolated and characterized. The macrolactone of ruckerbactin was not detected. The presence of LArg in ruckerbactin makes it the diastereomer of trivanchrobactin with DArg. The electronic circular dichroism spectra of Fe(III)–ruckerbactin and Fe(III)–trivanchrobactin reveal the opposite enantiomeric configurations at the Fe(III) sites. Fe(III)–ruckerbactin adopts the Δ configuration, and Fe(III)–trivanchrobactin adopts the Λ configuration. Y. ruckeri YRB was also found to produce the antimicrobial agent holomycin (4).