6279-35-2

Basic information

• Product Name: 1-Phenyl-2-(4-chlorophenyl)ethanol
• Synonyms: 1-Phenyl-2-(4-chlorophenyl)ethanol;p-Chloro-α-phenylphenethyl alcohol
• CAS NO: 6279-35-2
• Molecular Formula: C₁₄H₁₃ClO
• Molecular Weight: 232.7054
• Mol File: 6279-35-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 338°Cat760mmHg
• Flash Point: 158.2°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 3.93E-05mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-Phenyl-2-(4-chlorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-(4-chlorophenyl)ethanol(6279-35-2)
• EPA Substance Registry System: 1-Phenyl-2-(4-chlorophenyl)ethanol(6279-35-2)

Safety Data

• Hazardous Substances Data: 6279-35-2(Hazardous Substances Data)

Usage

General Description

1-Phenyl-2-(4-chlorophenyl)ethanol, also known as chlorpheniramine, is an antihistamine medication used to relieve symptoms of allergies, such as sneezing, itching, and watery eyes. It works by blocking the action of histamine, a substance in the body that causes allergy symptoms. This chemical is a white, crystalline powder that is often formulated as a tablet or syrup for oral administration. It is also sometimes used in combination with other medications to treat symptoms of the common cold. Chlorpheniramine is considered safe and effective when used as directed, but it may cause drowsiness and other side effects in some individuals. It is important to follow the dosage instructions provided by a healthcare professional to avoid potential adverse effects.

InChI:InChI=1/C14H13ClO/c15-13-8-6-11(7-9-13)10-14(16)12-4-2-1-3-5-12/h1-9,14,16H,10H2

Upstream product

• 100-52-7 benzaldehyde 
• 874-72-6 4-chlorobenzylmagnesium chloride 
• 96-09-3 styrene oxide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1657-49-4 1-chloro-4-[(Z)-2-phenylethenyl]benzene 
• 1657-50-7 (E)-1-(4-chlorophenyl)-2-phenylethene 
• 95458-82-5 diethyl 4-chlorobenzyl phosphate 
• 78358-09-5 40chlorobenzyl methanesulfonate 
• 60-29-7 diethyl ether 
• 28291-10-3 trans-2-(4-chlorobenzenyl)-3-phenyl-oxirane 
• 75772-21-3 1-chloro-4-<(methylseleno)methyl>benzene 

Relevant articles and documents

Cobalt Catalyst Determines Regioselectivity in Ring Opening of Epoxides with Aryl Halides

Ring-opening of epoxides furnishing either linear or branched products belongs to the group of classic transformations in organic synthesis. However, the regioselective cross-electrophile coupling of aryl epoxides with aryl halides still represents a key challenge. Herein, we report that the vitamin B12/Ni dual-catalytic system allows for the selective synthesis of linear products under blue-light irradiation, thus complementing methodologies that give access to branched alcohols. Experimental and theoretical studies corroborate the proposed mechanism involving alkylcobalamin as an intermediate in this reaction.

Direct preparation of benzylic manganese reagents from benzyl halides, sulfonates, and phosphates and their reactions: Applications in organic synthesis

The use of highly active manganese (Mn)*, prepared by the Rieke method, was investigated for the direct preparation of benzylic manganese reagents. The oxidative addition of the highly active manganese to benzylic halides was easily completed under mild conditions. Moreover, benzylic manganese sulfonates and phosphates were prepared by direct oxidative addition of Mn* to the carbon-oxygen bonds of benzylic sulfonates and phosphates. The resulting benzylic manganese reagents were found to undergo cross-coupling reactions with a variety of electrophiles. Most of these reactions were carried out in the absence of any transition metal catalyst under mild conditions. In addition, the use of highly active manganese was also studied for preparation of homo-coupled products of functionalized benzyl halides without transition metal catalysts. These useful approaches provided not only a facile synthetic route to the preparation of resoricinolic lipids but a facile synthesis of functionalized 4-benzylpyridines by regioselective and chemo selective γ-addition of benzylic group to N-alkoxycarbonylpyridinum salts.

A new synthetic protocol for the direct preparation of organomanganese reagents; organomanganese tosylates and mesylates

A new synthetic route to organomanganese sulfonate reagents has been developed. These useful reagents can be readily prepared via direct oxidative addition of highly reactive manganese to carbon-oxygen bonds of the corresponding tosylates and mesylates under mild conditions.