62802-42-0 Usage
Description
2-Chloro-5-fluoropyrimidine is an organic compound with the molecular formula C4H3ClFN2. It is a colorless to light yellow liquid and serves as a crucial intermediate in the synthesis of various biologically active molecules, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
2-Chloro-5-fluoropyrimidine is used as a key intermediate for the preparation of 2,4-disubstituted-5-fluoropyrimidine, which is a biologically active molecule found in anticancer agents like 5-fluorouracil. It plays a significant role in the development of novel cancer treatments.
2-Chloro-5-fluoropyrimidine is also used as a starting material for the preparation of:
1. 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction. These compounds have potential applications in the development of new pharmaceuticals.
2. 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate used in the synthesis of benzamide scaffolds. These benzamides are potent antagonists against P2X7 receptors, which are involved in various physiological processes and could be targeted for therapeutic intervention.
3. 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine. 2-Chloro-5-fluoropyrimidine acts as a potent inhibitor of the JAK2 kinase, which is a target for various diseases, including cancer and inflammatory conditions.
Preparation
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.
Check Digit Verification of cas no
The CAS Registry Mumber 62802-42-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,8,0 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 62802-42:
(7*6)+(6*2)+(5*8)+(4*0)+(3*2)+(2*4)+(1*2)=110
110 % 10 = 0
So 62802-42-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClFNO2/c7-5-4(8)3(6(10)11)1-2-9-5/h1-2H,(H,10,11)
62802-42-0Relevant articles and documents
IMIDAZOTRIAZINONE COMPOUNDS
-
Paragraph 0639; 0640; 0641, (2013/10/08)
The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.
SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME
-
Page/Page column 92-93, (2008/06/13)
Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
-
, (2019/08/08)
Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.