62855-39-4

Basic information

• Product Name: 4-Cyanonaphthalene-1-carboxaldehyde
• Synonyms: 4-Cyanonaphthalene-1-carboxaldehyde;4-formyl-1-naphthonitrile
• CAS NO: 62855-39-4
• Molecular Formula: C12H7NO
• Molecular Weight: 181.19008
• Mol File: 62855-39-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Cyanonaphthalene-1-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyanonaphthalene-1-carboxaldehyde(62855-39-4)
• EPA Substance Registry System: 4-Cyanonaphthalene-1-carboxaldehyde(62855-39-4)

Safety Data

• Hazardous Substances Data: 62855-39-4(Hazardous Substances Data)

Upstream product

• 41014-20-4 4-bromomethyl-1-naphthonitrile 
• 219685-17-3 trifluoromethanesulfonic acid 4-formylnaphthalen-1-yl ester 
• 92616-49-4 4-bromonaphthalene-1-carbonitrile 
• 6627-78-7 1-bromo-4-methylnaphthalene 
• 90-12-0 1-Methylnaphthalene 
• 36062-93-8 1-cyano-4-methylnaphthalene 

Downstream Products

• 123674-43-1 4-cyano-1-naphthylmethyl phenylacetate 
• 3839-19-8 4-cyano-1-naphthoic acid 

Relevant articles and documents

INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR

Chromanone compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the inhibition of antigen presentation by HLA-DR.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.