62868-39-7

Basic information

• Product Name: 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE
• Synonyms: 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE;1-(4-Methoxyphenyl)imidazolidin-2-one
• CAS NO: 62868-39-7
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21448
• Mol File: 62868-39-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-212
• Appearance: /
• Density: 1.197 g/cm³
• Refractive Index: 1.561
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE(62868-39-7)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE(62868-39-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 62868-39-7(Hazardous Substances Data)

Usage

General Description

1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE is a chemical compound with the molecular formula C11H13NO2. It is an imidazolidinone derivative with a tetrahydro-2H-imidazol-2-one core and a 4-methoxyphenyl substituent. 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE is used in the pharmaceutical industry, particularly in the development of potential drug candidates. It may have biological activity and is studied for its potential therapeutic effects, such as in the treatment of neurological disorders and as an analgesic. The exact mechanism of action and specific uses of 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE are still under investigation and may vary depending on the intended application.

InChI:InChI=1/C10H12N2O2/c1-14-9-4-2-8(3-5-9)12-7-6-11-10(12)13/h2-5H,6-7H2,1H3,(H,11,13)

Upstream product

• 120-93-4 imidazolidone 
• 696-62-8 para-iodoanisole 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 104-94-9 4-methoxy-aniline 
• 24455-93-4 N-(4-methoxyphenyl)ethane-1,2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 87919-18-4 1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea 
• 497-25-6 dimethylenecyclourethane 

Downstream Products

• 2033-35-4 4,5-dihydro-1-(4-methoxyphenyl)-3-methylimidazol-2(1H)-one 
• 62868-37-5 3-(4-methoxy-phenyl)-2-oxo-imidazolidine-1-carbonyl chloride 

Relevant articles and documents

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.