6287-94-1

Basic information

• Product Name: (biphenyl-4-ylmethylidene)propanedioic acid
• CAS NO: 6287-94-1
• Molecular Formula: C₁₆H₁₂O₄
• Molecular Weight: 268.2641
• Mol File: 6287-94-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 495.1°C at 760 mmHg
• Flash Point: 267.3°C
• Density: 1.332g/cm³
• Vapor Pressure: 1.28E-10mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: (biphenyl-4-ylmethylidene)propanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (biphenyl-4-ylmethylidene)propanedioic acid(6287-94-1)
• EPA Substance Registry System: (biphenyl-4-ylmethylidene)propanedioic acid(6287-94-1)

Safety Data

• Hazardous Substances Data: 6287-94-1(Hazardous Substances Data)

Usage

Description

(biphenyl-4-ylmethylidene)propanedioic acid, with the chemical formula C16H14O4, is a derivative of propanedioic acid, also known as malonic acid. (biphenyl-4-ylmethylidene)propanedioic acid features a 4-phenylbenzylidene functional group and is widely utilized in organic synthesis. Its structure, which includes a biphenyl moiety, may confer unique properties and reactivity, making it valuable for various applications in the chemical research and industry. It is crucial to handle and store this compound with appropriate safety measures due to its potential hazards and reactivity.

Uses

Used in Organic Synthesis:
(biphenyl-4-ylmethylidene)propanedioic acid is used as a building block for the preparation of various organic molecules, contributing to the synthesis of a diverse range of compounds.
Used in Chemical Research:
(biphenyl-4-ylmethylidene)propanedioic acid is employed as a research tool in chemical laboratories, where its unique properties and reactivity are explored for potential applications and advancements in the field.
Used in Pharmaceutical Industry:
(biphenyl-4-ylmethylidene)propanedioic acid may be used as a starting material or intermediate in the development of new pharmaceutical compounds, given its structural features and synthetic utility.
Used in Material Science:
(biphenyl-4-ylmethylidene)propanedioic acid's unique structure and properties could be harnessed in the development of new materials with specific characteristics, such as improved stability or reactivity, for various industrial applications.
Used in Chemical Industry:
(biphenyl-4-ylmethylidene)propanedioic acid can be utilized in the chemical industry for the production of specialty chemicals, intermediates, or additives that require its specific structural features.

Upstream product

• 644-08-6 4-Methylbiphenyl 
• 3218-36-8 4-Phenylbenzaldehyde 
• 105-53-3 diethyl malonate 
• 141-82-2 malonic acid 

Downstream Products

• 115370-06-4 (R)-2-((R)-2-Acetylsulfanylmethyl-3-biphenyl-4-yl-propionylamino)-3-(4-methyl-benzylsulfanyl)-propionic acid 
• 115370-07-5 (R)-2-((S)-2-Acetylsulfanylmethyl-3-biphenyl-4-yl-propionylamino)-3-(4-methyl-benzylsulfanyl)-propionic acid 
• 13026-23-8 (2E)-3-(1,1'-biphenyl-4-yl)acrylic acid 

Relevant articles and documents

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.