6290-24-0Relevant articles and documents
Ligand-free Cu(ii)-catalyzed aerobic etherification of aryl halides with silanes: An experimental and theoretical approach
Ahmed, Muhammad Naeem,Ahmad, Khalil,Yasin, Khawaja Ansar,Farooq, Tayyaba,Khan, Bilal Ahmad,Roy, Soumendra K.
, p. 11316 - 11333 (2019/07/31)
Owing to their wide occurrence in nature and immense applications in various fields, the synthesis of aryl alkyl ethers has remained a focus of interest. In contrast to the conventional/traditional methods of etherification, herein, we have reported a more efficient method, which is better yielding and more general in application. The etherification of aryl halides by alkoxy/phenoxy silanes was catalyzed by copper acetate in the presence of cesium carbonate and oxygen in DMF at 145 °C. All the as-synthesized compounds were characterized via the 1H-NMR and 13C-NMR spectroscopic techniques. Density functional theory calculations using the B3LYP functional were performed to elucidate the reaction mechanism. The C-O coupling reaction between 2-nitroiodobenzene and tetramethoxysilane was used as a model reaction. The activation energy barriers for the generation of catalytic species (31.6 kcal mol-1) and the σ-bond metathesis (16.0 kcal mol-1), oxidative addition/reductive elimination (20.3 kcal mol-1), halogen atom transfer (19.2 kcal mol-1) and single electron transfer (SET) (29.5 kcal mol-1) mechanisms for the C-O coupling reaction were calculated. Calculations for the key reaction steps were repeated with the B3PW91, PBEH1PBE, wB97XD, CAM-B3LYP and mPW1LYP functionals. The formation of catalytic species via a single electron transfer reaction between tetramethoxysilane and copper acetate, formation of methoxy radicals and methoxylation of copper showed an overall energy barrier of 31.6 kcal mol-1, and therefore is the rate determining step.
Synthetic method for medical intermediate ethyl o-ethoxybenzoate of o-ethoxybenzoate
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Paragraph 0013; 0014, (2016/11/17)
The invention discloses a synthetic method for a medical intermediate ethyl o-ethoxybenzoate of o-ethoxybenzoate. The synthetic method includes the following steps that 0.32 mol of salicylic acid, 0.65 mol of sodium hydrogen sulfite solutions, 0.31 mol of stannous chloride and 300 ml of sodium chloride solutions are added into a reacting container provided with a stirrer, a reflux condenser and a dropping funnel, the stirring speed is controlled to be 130-170 rpm, and the temperature of the solution is reduced to 5-9 DEG C; 1.31-1.33 mol of ethylamine is dropwise added, and continuous stirring is carried out for 8-9 h after the ethylamine is added; 300 ml of cyclohexane is added, and after 80-120 min, an organic layer is separated; the mixture is subjected to salt solution washing for 3-5 times, dehydrated through a dehydrating agent and subjected to reduced pressure distillation, the fraction obtained at the temperature of 105-115 DEG C is collected, recrystallization is carried out in isopropyl alcohol, and the crystal ethyl o-ethoxybenzoate is obtained, wherein the mass percent of the sodium hydrogen sulfite solutions ranges from 30% to 35%, the mass percent of the sodium chloride solutions ranges from 15% to 20%, and the mass percent of the cyclohexane ranges from 55% to 60%.
New cyclic skin whiteninig agent
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Paragraph 0115-0116, (2016/11/21)
In the present invention, provided is a skin whitening agent, which is easily synthesized without side effects for skin and has an outstanding effect of inhibiting pigmentation on skin due to an outstanding effect of inhibiting the creation of melanine where a cyclic derivative compound or pharmaceutically acceptable salt thereof has a chemical structure in formula (I) and is accordingly used to achieve the purpose of the present invention. In the present invention, provided is a cyclic derivative compound or pharmaceutically acceptable salt thereof, which has an effect of whitening skin and a chemical structure in formula (I) where A is derived from an aromatic cyclic compound; B is derived from among hydrogen, O which is oxo, NH_2 which is amino, NH which is imino, C1-C10 of saturated or unsaturated straight or branched chain alkyl group, alkoxy, mono alkyl amino group or dialkyl amino group; and C_n, C_n+1 and C_n+2 are three neighboring carbons in the cyclic compound wherein n is a positive integer.COPYRIGHT KIPO 2015