6290-94-4Relevant articles and documents
Tunability in polyatomic molecule diffusion through tunneling versus pacing
Cheng, Zhihai,Chu, Eric S.,Sun, Dezheng,Kim, Daeho,Zhu, Yeming,Luo, Miaomiao,Pawin, Greg,Wong, Kin L.,Kwon, Ki-Young,Carp, Robert,Marsella, Michael,Bartels, Ludwig
, p. 13578 - 13581 (2010)
The diffusion temperature of molecular 'walkers', molecules that are capable of moving unidirectionally across a substrate violating its symmetry, can be tuned over a wide range utilizing extension of their aromatic backbone, insertion of a second set of substrate linkers (converting bipedal into quadrupedal species), and substitution on the ring. Density functional theory simulation of the molecular dynamics identifies the motion of the quadrupedal species as pacing (as opposed to trotting or gliding). Knowledge about the diffusion mode allows us to draw conclusions on the relevance of tunneling to the surface diffusion of polyatomic organic molecules.
Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione
Davioud-Charvet, Elisabeth,Roignant, Matthieu,Trometer, Nathan
, (2022/03/01)
Herein, we report a safe and economical multigram synthesis of 6-fluoromenadione, an intermediate in the synthesis of novel biologically active agents. The key to this six-step sequence process involves the condensation of the readily available starting 4′-fluoropropiophenone and glyoxylic acid, a bromination-elimination sequence from 7-fluoro-3-methyltetral-1-one allowing aromatization of the naphthol intermediate, which is then oxidized into the corresponding 6-fluoromenadione. The multigram process has been demonstrated from 25 g of starting material scale with an improved overall yield of 50% and then applied to five other 7-substituted 3-methyltetralones and their corresponding 6-substituted menadiones.
Copper-mediated oxidative trifluoromethylthiolation of quinones
Li, Chao,Zhang, Ke,Xu, Xiu-Hua,Qing, Feng-Ling
supporting information, p. 6273 - 6275 (2015/10/20)
A novel copper-mediated oxidative trifluoromethylthiolation of quinones was developed. This protocol provided an efficient and practical approach to a series of trifluoromethylthiolated quinones.
Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
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Paragraph 0098-0101, (2013/03/26)
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and their use as antimalarial or antischistosomal agents.
