6291-23-2

Basic information

• Product Name: 4-morpholinophenol
• Synonyms: 4-morpholinophenol;4-Morpholin-4-yl-phenol;4-(4-Morpholinyl)phenol;4-(4-morpholino)phenol
• CAS NO: 6291-23-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• EINECS: 228-542-5
• Product Categories: pharmacetical
• Mol File: 6291-23-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.185g/cm³
• Vapor Pressure: 8.94E-06mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 4-morpholinophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-morpholinophenol(6291-23-2)
• EPA Substance Registry System: 4-morpholinophenol(6291-23-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6291-23-2(Hazardous Substances Data)

Usage

General Description

4-Morpholinophenol, also known as 4-(4-morpholinophenyl)morpholin-3-one, is a chemical compound that belongs to the class of morpholine derivatives. It is a white to off-white crystalline powder with a molecular formula of C11H14N2O2. This chemical is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been identified as an intermediate in the production of various chemicals, including dyes, pigments, and rubber chemicals. Moreover, 4-morpholinophenol has been reported to possess antioxidant and anti-inflammatory properties, which also makes it a potential candidate for use in skin care and cosmetic products. However, it is important to handle and use 4-morpholinophenol with caution, as it may present health and environmental hazards due to its toxic and irritant properties.

InChI:InChI=1/C10H13NO2/c12-10-3-1-9(2-4-10)11-5-7-13-8-6-11/h1-4,12H,5-8H2

Upstream product

• 123-30-8 4-amino-phenol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 110-91-8 morpholine 
• 106-41-2 4-bromo-phenol 
• 6793-92-6 p-benzyloxyphenylbromide 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 540-38-5 p-Iodophenol 
• 70291-67-7 N-(4-chlorophenyl)morpholine 

Downstream Products

• 67914-39-0 4-{4-[2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-morpholine 
• 1149748-56-0 C₁₅H₂₂BrNO₂ 

Relevant articles and documents

Preparation and application of aminourea-sensitive amine oxidase inhibitor

The invention provides preparation and application of an aminourea-sensitive amine oxidase inhibitor. Specifically, the invention discloses a compound as shown in a formula I which is described in thespecification or a stereoisomer or racemate or a pharmaceutically acceptable salt thereof. The invention also discloses the capability of the compound in inhibition of aminourea-sensitive amine oxidase.

Ultrafine hybrid Cu2O-Fe2O3 nanoparticles stabilized by hexaphenylbenzene-based supramolecular assemblies: A photocatalytic system for the Ullmann-Goldberg coupling reaction

Ultrafine hybrid Cu2O-Fe2O3 NPs have been prepared using the supramolecular assemblies of hexaphenylbenzene (HPB) derivative 3 as nanoreactors and stabilizers. The as-prepared hybrid Cu2O-Fe2O3 NPs serve as an efficient and recyclable photocatalytic system for carrying out C-N coupling between aryl halides and various amines (aliphatic, aromatic and N-heterocyclic) at room temperature in mixed aqueous media under visible light irradiation. Amazingly, Cu2O-Fe2O3 NPs also exhibited high efficiency in the reactions involving the synthesis of biologically important N-substituted carbazole derivatives. The work being presented in this article demonstrates the preparation of a 'dip strip' coated with the as-prepared catalytic system and utilization of this paper strip as a recyclable and portable heterocatalytic system for carrying out the Ullmann-Goldberg coupling.

Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions

The combination of Cu(acac)2 and N,N′-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide (BHMPO) provides a powerful catalytic system for hydroxylation of (hetero)aryl halides. A wide range of (hetero)aryl chlorides bearing either electron-donating or -withdrawing groups proceeded well at 130 °C, delivering the corresponding phenols and hydroxylated heteroarenes in good to excellent yields. When more reactive (hetero)aryl bromides and iodides were employed, the hydroxylation reactions completed at relatively low temperatures (80 and 60 °C, respectively) at low catalytic loadings (0.5 mol % Cu).