6291-88-9

Basic information

• Product Name: 3,3'-sulphonyldipropionic acid
• Synonyms: 3,3'-sulphonyldipropionic acid;3,3'-Sulfonylbis(propanoic acid);3,3'-Sulfonyldipropionic acid;3-(2-Carboxy-ethanesulfonyl)-propionic acid
• CAS NO: 6291-88-9
• Molecular Formula: C₆H₁₀O₆S
• Molecular Weight: 210.205
• EINECS: 228-546-7
• Mol File: 6291-88-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,3'-sulphonyldipropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-sulphonyldipropionic acid(6291-88-9)
• EPA Substance Registry System: 3,3'-sulphonyldipropionic acid(6291-88-9)

Safety Data

• Hazardous Substances Data: 6291-88-9(Hazardous Substances Data)

Usage

General Description

3,3'-sulphonyldipropionic acid is a chemical compound with the molecular formula C9H14O6S. It is a dicarboxylic acid with a sulfonic acid group, and is commonly used as an intermediate in the synthesis of various organic compounds. It is a white crystalline solid that is soluble in water and polar organic solvents. 3,3'-sulphonyldipropionic acid is used in the production of polymers, including polyesters and polyamides, and as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as a raw material in the production of detergents and surfactants due to its surfactant properties. Additionally, it has potential applications in the development of new materials, such as ion-exchange resins and functional materials for various industrial purposes.

Upstream product

• 111-17-1 4-thiaheptane-1,7-dioic acid 
• 57-57-8 β-Propiolactone 
• 3234-31-9 4,4-dioxo-4λ⁶-thia-heptanedinitrile 
• 3680-08-8 3,3'-sulfinyldipropionic acid 
• 7726-95-6 bromine 
• 7647-01-0 hydrogenchloride 
• 149-44-0 rongalite 
• 79-10-7 acrylic acid 

Downstream Products

• 52329-65-4 disodium 3-sulfinopropanoate 
• 7355-12-6 4,4-dioxo-4λ⁶-thia-heptanedioic acid diethyl ester 
• 5450-67-9 Bis-(2-methoxycarbonyl-ethyl)-sulfon 

Relevant articles and documents

The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase

Thiol dioxygenation is the initial oxidation step that commits a thiol to important catabolic or biosynthetic pathways. The reaction is catalyzed by a family of specific non-heme mononuclear iron proteins each of which is reported to react efficiently with only one substrate. This family of enzymes includes cysteine dioxygenase, cysteamine dioxygenase, mercaptosuccinate dioxygenase, and 3-mercaptopropionate dioxygenase. Using sequence alignment to infer cysteine dioxygenase activity, a cysteine dioxygenase homologue from Pseudomonas aeruginosa (p3MDO) has been identified. Mass spectrometry of P. aeruginosa under standard growth conditions showed that p3MDO is expressed in low levels, suggesting that this metabolic pathway is available to the organism. Purified recombinant p3MDO is able to oxidize both cysteine and 3-mercaptopropionic acid in vitro, with a marked preference for 3-mercaptopropionic acid. We therefore describe this enzyme as a 3-mercaptopropionate dioxygenase. M?ssbauer spectroscopy suggests that substrate binding to the ferrous iron isthrough the thiol but indicates that each substrate could adopt different coordination geometries. Crystallographic comparison with mammalian cysteine dioxygenase shows that the overall active site geometry is conserved but suggests that the different substrate specificity can be related to replacement of an arginine by a glutamine in the active site.

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.