6295-31-4

Basic information

• Product Name: N-benzyl-2-hydroxypropanamide
• CAS NO: 6295-31-4
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 6295-31-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393.7°C at 760 mmHg
• Flash Point: 191.9°C
• Density: 1.126g/cm³
• Vapor Pressure: 6.63E-07mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: N-benzyl-2-hydroxypropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-hydroxypropanamide(6295-31-4)
• EPA Substance Registry System: N-benzyl-2-hydroxypropanamide(6295-31-4)

Safety Data

• Hazardous Substances Data: 6295-31-4(Hazardous Substances Data)

Upstream product

• 57-55-6 propylene glycol 
• 100-46-9 benzylamine 
• 95-96-5 D,L-lactide 
• 6653-71-0 N-benzyl-2-bromopropanamide 
• 547-64-8 methyl lactate 
• 97-64-3 ethyl 2-hydroxypropionate 

Downstream Products

• 1360567-09-4 1-(benzylamino)-1-oxopropan-2-yl methanesulfonate 
• 142713-67-5 N-benzyl-2-(phenoxy)propanamide 
• 124371-71-7 N?benzyl?2?phenoxypropanamide 
• 1360567-16-3 N-benzyl-2-(ethylthio)propanamide 
• 1309658-34-1 2-azido-N-benzylpropanamide 
• 109017-91-6 N-(benzyl)-4,5-dimethyl-4-oxazolin-2-one 

Relevant articles and documents

Metal-ligand cooperation in the catalytic dehydrogenative coupling (DHC) of polyalcohols to carboxylic acid derivatives

Several polyols, which are easily available from sugars through biochemical conversion or hydrogenolytic cleavage, are directly converted into carboxylic acids and amides. This efficient dehydrogenative coupling process, catalyzed by a rhodium(I) diolefin amido complex, is an attractive approach for the production of organic fine chemicals from renewable resources. This method tolerates the presence of several hydroxy groups and can be extended to the direct synthesis of lactams from the corresponding amino alcohols under mild conditions.

Acyl transfer catalysis with 1,2,4-Triazole anion

1,2,4-Triazole anion has been identified as an active acyl transfer catalyst suitable for the aminolysis and transesterification of esters.

BASE-PROMOTED CYCLOCOUPLING REACTION OF 2-BROMOPROPANAMIDES AND 2-BROMOACETAMIDES WITH DMF

In the presence of a suitable base, representative 2-bromopropanamides 4 and 2-bromoacetamides 5 undergo cyclocondensation onto the carbonyl group of DMF to yield the 2-(dimethylamino)oxazolidin-4-ones 6 and 10, respectively.Of these cyclic orthoester ami