6299-67-8

Basic information

• Product Name: 2,3-DIMETHOXYANILINE
• Synonyms: Dimethoxyaniline;2,3-Dimethoxy-phenylamine;Nsc44873;2,3-Dimethoxyaniline ,98%;BenzenaMine, 2,3-diMethoxy-;(2,3-dimethoxyphenyl)amine hydrochloride
• CAS NO: 6299-67-8
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.17844
• Mol File: 6299-67-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 93 °C / 1.4mmHg
• Appearance: /
• Density: 1,14 g/cm3
• Refractive Index: 1.5630-1.5650
• Storage Temp.: Refrigerator
• PKA: 4.12±0.10(Predicted)
• CAS DataBase Reference: 2,3-DIMETHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHOXYANILINE(6299-67-8)
• EPA Substance Registry System: 2,3-DIMETHOXYANILINE(6299-67-8)

Safety Data

• Statements: 20/21/22-36/37/38-36/38
• Safety Statements: 26-36/37/39-51-20/21
• HazardClass: IRRITANT
• Hazardous Substances Data: 6299-67-8(Hazardous Substances Data)

Usage

Description

2,3-Dimethoxyaniline, also known as 2,3-dimethoxyaniline, is an organic compound with the chemical formula C8H11NO2. It is a derivative of aniline, featuring two methoxy groups at the 2nd and 3rd positions of the benzene ring. 2,3-DIMETHOXYANILINE is known for its various applications in the chemical and pharmaceutical industries due to its unique chemical properties.

Uses

Used in Hair Dye Industry:
2,3-Dimethoxyaniline is used as an intermediate chemical for the composition of hair dyes. It is particularly utilized in the formulation of hair dyes consisting of a monoaminobenzene and a metal catalyst. The presence of the methoxy groups in the compound enhances the dye's ability to penetrate hair shafts, providing better coloration and improved hair dye performance.

Upstream product

• 116668-84-9 3-nitroveratrole 
• 91-16-7 1,2-dimethoxybenzene 
• 2785-95-7 3-lithio-1,2-dimethoxybenzene 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 182205-44-3 benzyl 2,3-dimethoxyphenylcarbamate 
• 2150-42-7 methyl 2,3-dimethoxybenzoate 
• 343773-22-8 N-hydroxy-2,3-dimethoxybenzamide 
• 15969-08-1 6-methoxy-2-nitrophenol 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 56475-31-1 2.3-Dimethoxybenzoylazid 
• 101252-15-7 2,3-dichloro-5,6-dimethoxy-aniline 
• 116454-65-0 2,3-dimethoxytrifluoroacetanilide 
• 5701-87-1 3,4-dimethoxyanthranilic acid 

Downstream Products

• 857588-60-4 N-(2,3-dimethoxy-phenyl)-anthranilic acid 
• 99878-76-9 7,8-dimethoxy-4(1H)-quinolone 
• 99878-74-7 methyl 3-(2,3-dimethoxyanilino)acrylate 
• 99878-74-7 cis methyl 3-(2,3-dimethoxyanilino)acrylate 
• 183436-40-0 (2-Amino-3,4-dimethoxy-phenyl)-methylsulfanyl-acetic acid 
• 326479-09-8 N-(2,3-dimethoxyphenyl)-3-(phenylsulfanyl)propionamide 
• 121639-09-6 N-(2,3-dimethoxyphenyl)acetamide 
• 436810-54-7 3-(2,3-dimethoxyphenylamino)propionic acid 
• 258532-75-1 2-chloro-N-(2,3-dimethoxyphenyl)acetamide 
• 20734-71-8 2-methoxy-3-nitrophenol 
• 121001-06-7 2-methoxy-3-nitrobenzonitrile 
• 116668-84-9 3-nitroveratrole 
• 1046861-56-6 4,6-dichloro-2,3-dimethoxyaniline 
• 365242-41-7 N-(2,3-dimethoxyphenyl)-3-oxobutanamide 

Relevant articles and documents

SYNTHETIC MYCOTOXIN ADSORBENTS AND METHODS OF MAKING AND UTILIZING THE SAME

The present invention relates generally to molecularly imprinted polymers (MIPs). In particular, the present invention relates to reusable, ecologically friendly MIPs that can be produced in relatively large quantities, methods of producing the same, and

A base-mediated self-propagative Lossen rearrangement of hydroxamic acids for the efficient and facile synthesis of aromatic and aliphatic primary amines

A variety of aromatic and aliphatic hydroxamic acids were converted to the corresponding primary amines via base-mediated rearrangement. This rearrangement could proceed with less than 1 equiv. of K2CO3 in polar solvents under thermal conditions with no external reagents. This rearrangement has several features including no external activating agents needed for promoting the rearrangement, less than one equivalent of a base is sufficient for the reaction, and a clean reaction in which only carbon dioxide is produced as a by-product. A self-propagating mechanism via an isocyanate intermediate is proposed and elementary reaction steps, namely, chain propagation reactions are supported by experiments.

6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a potent and selective α1D-adrenoceptor antagonist

Previous results have shown that replacement of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective, α1-AR antagonist (S)-WB4101 [(S)-1] by phenyl, or by ortho,meta-fused cyclohexane, or especially by ortho,meta-fused benzene preferentially elicits α1D-AR antagonist affinity. Such observations inspired the design of four new analogues of 1 bearing, in lieu of the 2,6-dimethoxyphenoxy residue, a 6-methoxy-substituted 7-benzofuranoxy or 7-indolyloxy group or, alternatively, their corresponding 2,3-dihydro form. Of these new compounds, which maintain, rigidified, the characteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihydrobenzofuranoxy derivative exhibited the highest α1D-AR antagonist affinity (pA2 9.58) with significant α1D/ α1A and α1D/α1B selectivity. In addition, compared both to α1D-AR antagonists structurally related to 1 and to the well-known α1D-AR antagonist BMY7378, this derivative had modest 5-HT1A affinity and neutral α1-AR antagonist behavior.