630-60-4 Usage
Description
G-STROPHANTHIN, also known as Ouabain, is a potent cardiac glycoside derived from the seeds of Strophanthus gratus, Acokanthera ouabaio, and related species. It is an odorless, white crystalline substance, often found as an octahydrate. G-STROPHANTHIN is characterized by its cardiotonic and diuretic properties, making it a valuable compound in the treatment of various heart conditions.
Uses
Used in Pharmaceutical Industry:
G-STROPHANTHIN is used as a cardiotonic agent for the treatment of acute congestive heart failure. It helps in rapid digitalization, which is essential for managing this critical condition.
G-STROPHANTHIN is also used as an anti-arrhythmic agent for the treatment of atrial or nodal paroxysmal tachycardia and atrial flutter. Its ability to regulate heart rhythm makes it a crucial component in the management of these specific heart conditions.
Additionally, G-STROPHANTHIN is used as a diuretic, aiding in the removal of excess fluid from the body, which is beneficial in the treatment of heart-related edema and other fluid retention issues.
In the past, G-STROPHANTHIN was prescribed under the name strophanthuis as the purified seed extract, highlighting its historical significance in the field of cardiology.
Reactivity Profile
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
Health Hazard
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
Fire Hazard
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
Biological Activity
Selective Na + , K + -ATPase inhibitor.
Safety Profile
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Check Digit Verification of cas no
The CAS Registry Mumber 630-60-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 630-60:
(5*6)+(4*3)+(3*0)+(2*6)+(1*0)=54
54 % 10 = 4
So 630-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h12,14H,2-11,15-17H2,1H3,(H,19,20)
630-60-4Relevant articles and documents
Total synthesis of ouabagenin and ouabain
Zhang, Hongxing,Sridhar Reddy, Maddi,Phoenix, Serge,Deslongchamps, Pierre
, p. 1272 - 1275 (2008/12/22)
(Chemical Equation Presented) The highly oxygenated steroid ouabagenin (1b) and its glycoside ouabain (1a) were prepared by a strategy based on a polyanionic cyclization. Starting building blocks A and B were combined to give the key intermediate C and transformed into 1b in 27 steps. Finally, ouabagenin (1b) was converted into ouabain (1a) in six steps (see scheme).