6301-88-8 Usage
Description
(8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is a complex chemical compound that is a steroid derivative. It features a cyclopenta[a]phenanthrene ring system with a hydroxyl group at C-3 and C-17, an amino group at C-4, and a methyl group at C-13. Due to its structural characteristics, it may possess biological activities and should be handled with care in a laboratory setting.
Uses
Used in Pharmaceutical Industry:
(8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is used as a potential pharmaceutical agent for [application reason] due to its steroidal structure and possible biological activities.
Used in Research and Development:
In the field of research and development, (8S,9S,13S,14S,17S)-4-amino-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is used as a chemical compound for [application reason], such as exploring its potential interactions with biological systems or its use in the synthesis of other complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 6301-88-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,0 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6301-88:
(6*6)+(5*3)+(4*0)+(3*1)+(2*8)+(1*8)=78
78 % 10 = 8
So 6301-88-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO2/c1-18-9-8-11-10-4-6-15(20)17(19)13(10)3-2-12(11)14(18)5-7-16(18)21/h4,6,11-12,14,16,20-21H,2-3,5,7-9,19H2,1H3/t11-,12-,14+,16+,18+/m1/s1
6301-88-8Relevant articles and documents
Synthesis and conversion of primary and secondary 2-aminoestradiols into A-ring-integrated benzoxazolone hybrids and theirin vitroanticancer activity
Kovács, Ferenc,Gopisetty, Mohana K.,Adamecz, Dóra I.,Kiricsi, Mónika,Enyedy, éva A.,Frank, éva
, p. 13885 - 13896 (2021/04/22)
Hybrid systems are often endowed with completely different and improved properties compared to their parent compounds. In order to extend the chemical space toward sterane-based molecular hybrids, a number of estradiol-derived benzoxazol-2-ones with combined aromatic rings were synthesizedviathe corresponding 2-aminophenol intermediates. 2-Aminoestradiol was first prepared from estrone by a two-step nitration/reduction sequence under mild reaction conditions. Subsequent reductive aminations with different arylaldehydes furnished secondary 2-aminoestradiol derivatives in good yields. The proton dissociation processes of the aminoestradiols were investigated in aqueous solution by UV-visible spectrophotometric titrations to reveal their actual chemical forms at physiological pH. The determined pK1and pK2values are attributed to the+NH3or+NH2R and OH moieties, and both varied by the different R substituents of the amino group. Primary and secondary 2-aminoestradiols were next reacted with carbonyldiimidazole as a phosgene equivalent to introduce a carbonyl group with simultaneous ring-closure to give A-ring-fused oxazolone derivatives in high yields. The novel aminoestradiols and benzoxazolones were subjected toin vitrocytotoxicity analysis and were found to exert cancer cell specific activity.
