630107-83-4 Usage
Chemical Class
Pyrazolopyrimidine
Core Structure
Pyrazolopyrimidine
Substituents
4-chloro group, 2-fluorophenyl group
Biological Activity
Exhibits biological activity in medicinal chemistry
Potential Applications
Treatment of various diseases and conditions
Importance in Drug Development
Promising candidate for further research in the pharmaceutical industry
Molecular Weight
214.64 g/mol
Physical State
Solid
Appearance
Pale yellow or white crystalline solid
Solubility
Soluble in organic solvents such as DMSO, ethanol, and methanol
Melting Point
162-164°C
Spectroscopic Data
+ 1H NMR (proton nuclear magnetic resonance) in DMSO-d6
+ 13C NMR (carbon-13 nuclear magnetic resonance) in DMSO-d6
+ IR (infrared) spectroscopy
+ Mass spectrometry
+ Toxicity
Low toxicity (LD50 > 1000 mg/kg in mice)
+ Storage
Store in a cool, dry place in a sealed container
+ Handling
Handle with care and use appropriate personal protective equipment (PPE)
Check Digit Verification of cas no
The CAS Registry Mumber 630107-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,0,1,0 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 630107-83:
(8*6)+(7*3)+(6*0)+(5*1)+(4*0)+(3*7)+(2*8)+(1*3)=114
114 % 10 = 4
So 630107-83-4 is a valid CAS Registry Number.
630107-83-4Relevant articles and documents
Identification of novel GLUT inhibitors
Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig
, p. 1732 - 1737 (2016/07/27)
The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.
PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS
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Page 50, (2010/02/05)
Compounds having the formula (I), where all substituents are as defined herein, and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors.
