63026-85-7Relevant articles and documents
Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes
Gangjee, Aleem,Wang, Ying,Queener, Sherry F.,Kisliuk, Roy L.
, p. 1523 - 1531 (2007/10/03)
A series of eleven novel 2,6-diamino-5-[(2-substituted phenylamino)ethyl] pyrimidin-4(3H)-one derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) and thymidylate synthase (TS). The synthesis of analogues 2a-f, 3a and 3e