6307-12-6

Basic information

• Product Name: 2-[(2-nitrophenyl)carbamoyl]benzoic acid
• Synonyms: 2-[(2-Nitrophenyl)carbamoyl]benzoic acid; benzoic acid, 2-[[(2-nitrophenyl)amino]carbonyl]-
• CAS NO: 6307-12-6
• Molecular Formula: C₁₄H₁₀N₂O₅
• Molecular Weight: 286.2396
• Mol File: 6307-12-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 425.5°C at 760 mmHg
• Flash Point: 211.1°C
• Density: 1.485g/cm³
• Vapor Pressure: 5.35E-08mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 2-[(2-nitrophenyl)carbamoyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-nitrophenyl)carbamoyl]benzoic acid(6307-12-6)
• EPA Substance Registry System: 2-[(2-nitrophenyl)carbamoyl]benzoic acid(6307-12-6)

Safety Data

• Hazardous Substances Data: 6307-12-6(Hazardous Substances Data)

Usage

Molecular weight

298.24 g/mol

Class

Benzoic acids

Usage

Organic synthesis and pharmaceutical research

Functional groups

Nitro group, carbamoyl group, benzoic acid group

Contribution

Unique chemical properties and potential applications

Structure and reactivity

Useful in the development of pharmaceutical products and the study of biological processes

Potential applications

Organic chemistry synthesis of new compounds

Upstream product

• 85-44-9 phthalic anhydride 
• 88-74-4 2-nitro-aniline 
• 34442-94-9 N-(o-nitrophenyl)phthalimide 
• 60-29-7 diethyl ether 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 856803-29-7 N-methyl-N-(2-nitro-phenyl)-phthalamic acid 
• 856803-27-5 N-methyl-N-(2-nitro-phenyl)-phthalamic acid methyl ester 
• 856803-40-2 N-methyl-N-(2-nitro-phenyl)-phthalamide 

Relevant articles and documents

Aza-DielsAlder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

The synthesis of 5-substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)- ones via [4 + 2] imino-DielsAlder cyclization from N-aryl-3- hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2-substituted-aryl)-3- hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl)isoindolin-1-one analogues indicating steric hinderance as the cause of deviation. The probable mechanism of the reaction based on the results from X-ray crystallography and molecular modelling is discussed.

Reaction of cyclic anhydrides with aromatic amines: Part I - Synthesis of anilinic acids from phthalic anhydride

Some unreported anilinic acids 5a-j and 7 have been synthesised and their spectral data reported. Their in vitro insecticidal screening as protectants of maize (Zea mays) against Sitophilus zeamais shows 2-(N-naphthylcarbamoyl)benzoic acid 7 to be the most active member of the series.