6307-83-1

Basic information

• Product Name: 3-Bromo-5-nitrobenzoic acid
• Synonyms: 3-BROMO-5-NITROBENZOIC ACID;3-Bromo-5-nitrobenzoic aci;3-Bromo-5-carboxynitrobenzene;Benzoic acid, 3-bromo-5-nitro-
• CAS NO: 6307-83-1
• Molecular Formula: C₇H₄BrNO₄
• Molecular Weight: 246.01
• Product Categories: blocks;Bromides;Carboxes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic;NULL
• Mol File: 6307-83-1.mol
• Article Data: 33

Chemical Properties

• Melting Point: 159-161°C
• Boiling Point: 376.8 °C at 760 mmHg
• Flash Point: 181.7 °C
• Appearance: white to slightly yellow crystalline needles
• Density: 1.892 g/cm³
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.09±0.10(Predicted)
• BRN: 2051365
• CAS DataBase Reference: 3-Bromo-5-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-nitrobenzoic acid(6307-83-1)
• EPA Substance Registry System: 3-Bromo-5-nitrobenzoic acid(6307-83-1)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-50-22
• Safety Statements: 26-36/37/39-61-60-36/37-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 6307-83-1(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline needles

InChI:InChI=1/C7H4BrNO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11)/p-1

Upstream product

• 610-29-7 2-nitroterephthalic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 128-08-5 N-Bromosuccinimide 
• 121-92-6 3-nitrobenzoic acid 
• 136649-26-8 3-bromo-5-nitro-biphenyl 
• 64-19-7 acetic acid 
• 6307-87-5 methyl 3-bromo-5-nitrobenzoate 
• 355134-13-3 3-bromo-5-nitrobenzaldehyde 
• 618-84-8 3-amino-5-nitro-benzoic acid 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 924646-32-2 2'-fluoro-5-tetrazol-1-yl-biphenyl-3-carboxylic acid 
• 924646-31-1 3-amino-5-(2-fluorophenyl)benzoic acid 
• 1229442-64-1 ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1229442-63-0 ethyl 3-bromo-5-(cyclopropylmethoxy)benzoate 
• 870673-35-1 3-bromo-5-hydroxybenzoic acid ethyl ester 
• 1229441-30-8 3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylic acid 
• 1229441-29-5 ethyl 3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxylate 
• 1229442-69-6 ethyl 3-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1229442-68-5 ethyl 3-bromo-5-ethoxybenzoate 
• 1229441-19-3 5-(cyclopropylmethoxy)-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-N-(2-(piperidin-1-yl)ethyl)-[1,1'-biphenyl]-3-carboxamide 
• 1229441-31-9 N-cyclopropyl-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-ethoxy-[1,1'-biphenyl]-3-carboxamide 
• 1229441-17-1 5-(cyclopropylmethoxy)-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-[1,1'-biphenyl]-3-carboxylic acid 
• 1229441-16-0 ethyl 5-(cyclopropylmethoxy)-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-[1,1'-biphenyl]-3-carboxylate 
• 941294-16-2 3-bromo-N-isopropyl-5-nitrobenzamide 

Relevant articles and documents

Regioselective synthesis of carboxylic and fluoromethyl tetrazoles enabled by silver-catalyzed cycloaddition of diazoacetates and aryl diazonium salts

Here we present a dipolar [3 + 2] cycloaddition transformation of diazoacetates with arenediazonium salts under silver catalysis, thus offering a straightforward approach for the regioselective construction of carboxylic tetrazoles. Several merits are accompanied with this reaction including readily available starting reagents, broad coupling scope, high yields, and friendly reaction conditions. The synthetic value is further showcased by one-pot conversion of commercially available primary arylamines to tetrazoles and successful transformations of the cycloadducts into valuable 5-fluoromethyltetrazoles and an analogue of P2X3 receptor antagonist.

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Pyrimidine compounds and pharmaceutical composition for preventing or treating cancers comprising the same

The present invention relates to a pyrimidine compound having excellent FLT3 inhibitory activity, and a pharmaceutical composition for preventing or treating a cancer, including the same. The pyrimidine compound is represented by chemical formula 14, wherein the pyrimidine compound is selected from a stereoisomer, a tautomer, a solvate, and a pharmaceutically acceptable salt thereof. In the chemical formula 14, E^a is hydrogen, hydroxy or C_(1-4) alkoxy, and E^b is hydrogen, halogen, C_(1-4) alkyl or C_(1-4) fluoroalkyl.COPYRIGHT KIPO 2019