6314-72-3

Basic information

• Product Name: 4-PHENYLSULFAMOYL-BENZOIC ACID
• Synonyms: Nsc23008;4-[(phenylamino)sulfonyl]Benzoic acid;Benzoic acid, 4-[(phenylamino)sulfonyl]-;4-Phenylsulfamoyl-Benzoic Acid(WX612172)
• CAS NO: 6314-72-3
• Molecular Formula: C₁₃H₁₁NO₄S
• Molecular Weight: 277.3
• Mol File: 6314-72-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 485.3°C at 760 mmHg
• Flash Point: 247.3°C
• Appearance: /
• Density: 1.451g/cm³
• Vapor Pressure: 3.13E-10mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 4-PHENYLSULFAMOYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLSULFAMOYL-BENZOIC ACID(6314-72-3)
• EPA Substance Registry System: 4-PHENYLSULFAMOYL-BENZOIC ACID(6314-72-3)

Safety Data

• Hazardous Substances Data: 6314-72-3(Hazardous Substances Data)

Usage

General Description

4-Phenylsulfamoyl-benzoic acid is a chemical compound with the molecular formula C14H13NO4S. It is a white to yellow crystalline powder with a molecular weight of 295.32 g/mol. 4-PHENYLSULFAMOYL-BENZOIC ACID is often used as a crosslinking agent in the synthesis of polymers, particularly in the production of epoxy resins. It has also been studied for its potential anti-cancer properties, as it has shown to inhibit the growth of certain tumor cells. Additionally, 4-phenylsulfamoyl-benzoic acid has been used in the development of fluorescent probes for detecting biological molecules and in the production of dyes and pigments. Overall, this compound has various industrial and biomedical applications due to its versatile properties.

InChI:InChI=1/C13H11NO4S/c15-13(16)10-6-8-12(9-7-10)19(17,18)14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)

Upstream product

• 62-53-3 aniline 
• 69812-51-7 4-chlorosulfonyl-benzoic acid methyl ester 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 138-41-0 4-(aminosulfonyl)-benzoic acid 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 56768-46-8 4-cyano-N-phenyl-benzenesulfonamide 
• 68-34-8 phenyl toluenesulfonamide 

Downstream Products

• 114958-19-9 4-Phenylsulfamoyl-benzoyl chloride 
• 26737-96-2 N-phenyl-4-(N-phenylsulfamoyl)benzamide 

Relevant articles and documents

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

The rise of antibiotic resistance, especially in Staphylococcus aureus, and the increasing death rate due to multiresistant bacteria have been well documented. The need for new chemical entities and/or the identification of novel targets for antibacterial

Discovery of a type III inhibitor of LIM kinase 2 that binds in a DFG-out conformation

The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide were not only very potent at LIMK2 but also were extremely selective against a panel of other k